| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Roschger, Paul
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Postembedding Iodine Staining for Contrast‐Enhanced 3D Imaging of Bone Tissue Using Focused Ion Beam‐Scanning Electron Microscopy
- 20213D Interrelationship between Osteocyte Network and Forming Mineral during Human Bone Remodelingcitations
- 2020Heterogeneity of the osteocyte lacuno-canalicular network architecture and material characteristics across different tissue types in healing bonecitations
- 2019Mechanical properties of stingray tesserae: High-resolution correlative analysis of mineral density and indentation moduli in tessellated cartilagecitations
- 2017IFITM5 (BRIL) p.S40L mutation causing atypical type VI OI results in unique bone material phenotype impacting both endochondral ossification and chondrocyte development.
- 2017Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bonecitations
- 2016Evidence for a Role for Nanoporosity and Pyridinoline Content in Human Mild Osteogenesis Imperfectacitations
- 2015Unique micro- and nano-scale mineralization pattern of human osteogenesis imperfecta type VI bonecitations
- 2014Mapping dynamical mechanical properties of osteonal bone by scanning acoustic microscopy in time-of-flight modecitations
- 2014Changes in the Degree of Mineralization with Osteoporosis and its Treatmentcitations
- 2014Relationship between the v(2)PO(4)/amide III ratio assessed by Raman spectroscopy and the calcium content measured by quantitative backscattered electron microscopy in healthy human osteonal bonecitations
- 2014Mineral particle size in children with osteogenesis imperfecta type I is not increased independently of specific collagen mutationscitations
- 2013Computational and experimental methodology for site-matched investigations of the influence of mineral mass fraction and collagen orientation on the axial indentation modulus of lamellar bonecitations
- 2012Microcracks and Osteoclast Resorption Activity In Vitrocitations
- 2011Poorly Ordered Bone as an Endogenous Scaffold for the Deposition of Highly Oriented Lamellar Tissue in Rapidly Growing Ovine Bonecitations
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article
Computational and experimental methodology for site-matched investigations of the influence of mineral mass fraction and collagen orientation on the axial indentation modulus of lamellar bone
Abstract
Relationships between mineralization, collagen orientation and indentation modulus were investigated in bone structural units from the mid-shaft of human femora using a site-matched design. Mineral mass fraction, collagen fibril angle and indentation moduli were measured in registered anatomical sites using backscattered electron imaging, polarized light microscopy and nano-indentation, respectively. Theoretical indentation moduli were calculated with a homogenization model from the quantified mineral densities and mean collagen fibril orientations. The average indentation moduli predicted based on local mineralization and collagen fibers arrangement were not significantly different from the average measured experimentally with nanoindentation (p=0.9). Surprisingly, no substantial correlation of the measured indentation moduli with tissue mineralization and/or collagen fiber arrangement was found. Nano-porosity, micro-damage, collagen cross-links, non-collagenous proteins or other parameters affect the indentation measurements. Additional testing/simulation methods need to be considered to properly understand the variability of indentation moduli, beyond the mineralization and collagen arrangement in bone structural units.