| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Menzel, Andreas
TU Dortmund University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (52/52 displayed)
- 2024Enhancing damage prediction in bulk metal forming through machine learning-assisted parameter identificationcitations
- 2024A thermodynamically consistent phase transformation model for multiphase alloys : application to Ti6Al4V in laser powder bed fusion processescitations
- 2023Probing porosity in metals by electrical conductivity : Nanoscale experiments and multiscale simulationscitations
- 2023A large strain thermoplasticity model including recovery, recrystallisation and grain size effects
- 2023Probing porosity in metals by electrical conductivitycitations
- 2022ADAPT — A Diversely Applicable Parameter Identification Tool: Overview and full-field application examplescitations
- 2022Probing porosity in metals by electrical conductivity: Nanoscale experiments and multiscale simulations
- 2022A thermo-viscoplasticity model for metals over wide temperature ranges- application to case hardening steelcitations
- 2021An isogeometric finite element approach to fibre-reinforced composites with fibre bending stiffnesscitations
- 2021On the incorporation of a micromechanical material model into the inherent strain method—Application to the modeling of selective laser meltingcitations
- 2021On the incorporation of a micromechanical material model into the inherent strain method - application to the modeling of selective laser melting
- 2021Electrical and mechanical behaviour of metal thin films with deformation-induced cracks predicted by computational homogenisationcitations
- 2021A finite deformation isogeometric finite element approach to fibre-reinforced composites with fibre bending stiffnesscitations
- 2021An energy-relaxation-based framework for the modeling of magnetic shape memory alloyscitations
- 2021A computational framework for gradient‐enhanced damage
- 2021Mechanism-Based Modelling of Wear in Sheet-Bulk Metal Forming
- 2020An isogeometric finite element approach to fibre-reinforced composites with fibre bending stiffness
- 2020A computational phase transformation model for selective laser melting processescitations
- 2020An energy-relaxation-based framework for the modelling of magnetic shape memory alloyscitations
- 2020Gradient-enhanced modelling of damage for rate-dependent material behaviour-a parameter identification frameworkcitations
- 2020Gradient-enhanced modelling of damage for rate-dependent material behaviour - a parameter identification framework
- 2019Towards the simulation of Selective Laser Melting processes via phase transformation modelscitations
- 2019Thermo-Viscoplasticity for Case Hardening Steels at Finite Deformations and Wide Temperature Ranges
- 2019Finite-strain thermo-viscoplasticity for case-hardening steels over a wide temperature range
- 2018A PHYSICS–BASED MICROMECHANICAL MODEL FOR ELECTROACTIVE VISCO-ELASTIC POLYMERScitations
- 2018Laminate-based modelling of single and polycrystalline ferroelectric materialscitations
- 2018Computationally-efficient modeling of inelastic single crystal responses via anisotropic yield surfacescitations
- 2018On the Modelling of Thermo-Viscoplasticity of Case-Hardening Steels Over a Wide Temperature Range
- 2018Modelling Thermo‐Viscoplasticity of Case‐Hardening Steels Over Wide Temperature Ranges
- 2018Small-angle X-ray scattering tensor tomography : Model of the three-dimensional reciprocal-space map, reconstruction algorithm and angular sampling requirementscitations
- 2018A physics-based micromechanical model for electroactive viscoelastic polymerscitations
- 2017Case hardening steels modelled by thermo-viscoplasticity over a wide range of temperature
- 2017A finite deformation continuum modelling framework for curvature effects in fibre-reinforced nanocompositescitations
- 2017On Modeling of Thermo-Viscoplasticity of Case-Hardening Steels Over a Wide Temperature Range
- 2016Finite element simulation of coating-induced heat transfercitations
- 2016Analysis of viscoelastic soft dielectric elastomer generators operating in an electrical circuitcitations
- 2015Analytical investigation of structurally stable configurations in shape memory alloy-actuated platescitations
- 2015A kinematically-enhanced relaxation scheme for the modeling of displacive phase transformationscitations
- 2015Nanostructure surveys of macroscopic specimens by small-angle scattering tensor tomographycitations
- 2014Efficient Simulation of Nonlinear Heat Transfer during Thermal Spraying of Complex Workpiecescitations
- 2014Extremal states of energy of a double-layered thick-walled tube – application to residually stressed arteriescitations
- 2014Characterization of Elements Involved in Allosteric Light Regulation of Phosphodiesterase Activity by Comparison of Different Functional BlrP1 Statescitations
- 2013Density mapping of hardened cement paste using ptychographic X-ray computed tomographycitations
- 2013Structure and Dynamics of Soft Repulsive Colloidal Suspensions in the Vicinity of the Glass Transitioncitations
- 2012Partially relaxed energy potentials for the modelling of microstructurescitations
- 2012High-throughput roll-to-roll X-ray characterization of polymer solar cell active layerscitations
- 2012Phenomenological modeling of viscous electrostrictive polymerscitations
- 2010A micromechanically motivated model for ferroelectrics combined with polygonal finite elements
- 2009Enhanced Micromechanical Modelling of Martensitic Phase-Transitions Considering Plastic Deformationscitations
- 2008On the simulation of cohesive fatigue effects in grain boundaries of a piezoelectric mesostructurecitations
- 2008Investigation of microcracks in ferroelectric materials by application of a grain--boundary--motivated cohesive law
- 2008Nonlinear piezoelectric effects - towards physics-based computational modelling of micro-cracking, fatigue, and switching
Places of action
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article
Characterization of Elements Involved in Allosteric Light Regulation of Phosphodiesterase Activity by Comparison of Different Functional BlrP1 States
Abstract
Bacteria have evolved dedicated signaling mechanisms that enable the integration of a range of environmental stimuli and the accordant modulation of metabolic pathways. One central signaling molecule in bacteria is the second messenger cyclic dimeric GMP (c-di-GMP). Complex regulatory mechanisms for modulating c-di-GMP concentrations have evolved, in line with its importance for maintaining bacterial fitness under changing environmental conditions. One interesting example in this context is the blue-light-regulated phosphodiesterase 1 (BlrP1) of Klebsiella pneumoniae. This covalently linked system of a sensor of blue light using FAD (BLUF) and an EAL phosphodiesterase domain orchestrates the light-dependent down-regulation of c-di-GMP levels. To reveal details of light-induced structural changes involved in EAL activity regulation, we extended previous crystallographic studies with hydrogen–deuterium exchange experiments and small-angle X-ray scattering analysis of different functional BlrP1 states. The combination of hydrogen–deuterium exchange and small-angle X-ray scattering allows the integration of local and global structural changes and provides an improved understanding of light signaling via an allosteric communication pathway between the BLUF and EAL domains. This model is supported by results from a mutational analysis of the EAL dimerization region and the analysis of metal-coordination effects of the EAL active site on the dark-state recovery kinetics of the BLUF domain. In combination with structural information from other EAL domains, the observed bidirectional communication points to a general mechanism of EAL activity regulation and suggests that a similar allosteric coupling is maintained in catalytically inactive EAL domains that retain a regulatory function.