| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Roma-Rodrigues, Catarina
Universidade Lusófona
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2023Chitin-Glucan Complex Hydrogelscitations
- 2023Chitin-Glucan Complex Hydrogels ; Physical-Chemical Characterization, Stability, In Vitro Drug Permeation, and Biological Assessment in Primary Cellscitations
- 2023Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol ; Design, Characterization and Biological Propertiescitations
- 2023Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPolcitations
- 2019Structural characterization and biological properties of silver(I) tris(pyrazolyl)methane sulfonatecitations
- 2018EPR and electrochemical interpretation of bispyrazolylacetate anchored Ni(ii) and Mn(ii) complexes: Cytotoxicity and anti-proliferative activity towards human cancer cell linescitations
Places of action
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article
Structural characterization and biological properties of silver(I) tris(pyrazolyl)methane sulfonate
Abstract
<p>The water-soluble 1D helical coordination polymer [Ag(Tpms)]<sub>n</sub> (1) [Tpms = tris(pyrazolyl)methane sulfonate, <sup>−</sup>O<sub>3</sub>SC(pz)<sub>3</sub>; pz = pyrazolyl] was synthesized and fully characterized, its single-crystal X-ray diffraction analysis revealing the ligand acting as a bridging chelate N<sub>3</sub>-donor ligand. The antiproliferative potential of 1 was performed on two human tumour cell lines, A2780 and HCT116, and in normal fibroblasts, with a much higher effect in the former cell line (IC<sub>50</sub> of 0.04 μM) as compared to the latter cell line and to normal fibroblasts. Compound 1 does not alter cell cycle progression but interferes with the adherence of A2780 cells triggering cell apoptosis. Apoptosis appears to occur via the extrinsic pathway (no changes in mitochondria membrane potential, reactive oxygen species (ROS) and pro-apoptotic (B-cell lymphoma 2 (BCL-2) associated protein (BAX))/anti-apoptotic (BCL-2) ratio) being this hypothesis also supported by the presence of silver mainly in the supernatants of A2780 cells. Results also indicated that cell death via autophagy was triggered. Proteomic analysis allowed us to confirm that compound 1 is able to induce a stress response in A2780 cells that is related with its antiproliferative activity and the trigger of apoptosis.</p>