| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Warżajtis, Beata
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2020Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatincitations
- 2020Modulation of the structure of octahedral 1,3-pdta-nickel(II) complex by introducing methyl substituents at the central 1,3-propanediamine carbon atom: Stereospecific formation and the crystal structure of [Mg(H2O)5Ni(2,2-diMe-1,3-pdta)]·1.5H2Ocitations
- 2017Mononuclear gold(iii) complexes with l-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anioncitations
- 2017Mononuclear gold(III) complexes with phenanthroline ligands as efficient inhibitors of angiogenesis: A comparative study with auranofin and sunitinibcitations
- 2015Chalcogenated (S)-(-)-nicotine derivatives as chiral linkers for 1D coordination polymerscitations
- 2011Structural diversification of the coordination mode of divalent metals with 1,3-propanediaminetetraacetate (1,3-pdta): The missing crystal structure of the s-block metal complex [Sr<inf>2</inf>(1,3-pdta)(H<inf>2</inf>O) <inf>6</inf>]·H<inf>2</inf>Ocitations
- 2009Variety of polymorphic forms contrasted with uniform crystal packing in sparteine ML<inf>2</inf> complexes: Crystal structure, spectroscopic and magnetic properties of (-)-α-isosparteine and (-)-sparteine complexes with CuBr<inf>2</inf>citations
- 2008Coordination behaviour and two-dimensional-network formation in poly[[μ-aqua-diaqua-(μ5-propane-1,3-diyldinitrilo-tetra-acetato) -dilithium(I)-cobalt(II)] dihydrate]: The first example of an M <sup>II</sup>-1,3-pdta complex with a monovalent metal counter-ioncitations
- 2005Highly selective crystallization of metal(II) ions with 1,3-pdta ligand: Syntheses and crystal structures of the [Mg(H<inf>2</inf>O)<inf>6</inf>][Cd(1,3- pdta)(H<inf>2</inf>O)]·2H<inf>2</inf>O and two isomorphic [Zn(1,3-pdta)]<sup>2-</sup> complexescitations
- 2005Layered crystal structure of the trans(O<inf>5</inf>O<inf>6</inf>) isomer of potassium (1,3-propanediamine-N,N′-diacetato-N,N′-di-3- propionato)cobaltate(III) trihydrate, trans(O<inf>5</inf>O<inf>6</inf>)-K[Co(1, 3-pddadp)]·3H<inf>2</inf>O, stabilized by ionic, hydrogen bond and C=O dipolar interactionscitations
Places of action
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article
Mononuclear gold(III) complexes with phenanthroline ligands as efficient inhibitors of angiogenesis: A comparative study with auranofin and sunitinib
Abstract
<p>Gold(III) complexes with 1,7- and 4,7-phenanthroline ligands, [AuCl<sub>3</sub>(1,7-phen-κN7)] (1) and [AuCl<sub>3</sub>(4,7-phen-κN4)] (2) were synthesized and structurally characterized by spectroscopic (NMR, IR and UV–vis) and single-crystal X-ray diffraction techniques. In these complexes, 1,7- and 4,7-phenanthrolines are monodentatedly coordinated to the Au(III) ion through the N7 and N4 nitrogen atoms, respectively. In comparison to the clinically relevant anti-angiogenic compounds auranofin and sunitinib, gold(III)-phenanthroline complexes showed from 1.5- to 20-fold higher anti-angiogenic potential, and 13- and 118-fold lower toxicity. Among the tested compounds, complex 1 was the most potent and may be an excellent anti-angiogenic drug candidate, since it showed strong anti-angiogenic activity in zebrafish embryos achieving IC<sub>50</sub> value (concentration resulting in an anti-angiogenic phenotype at 50% of embryos) of 2.89 μM, while had low toxicity with LC<sub>50</sub> value (the concentration inducing the lethal effect of 50% embryos) of 128 μM. Molecular docking study revealed that both complexes and ligands could suppress angiogenesis targeting the multiple major regulators of angiogenesis, such as the vascular endothelial growth factor receptor (VEGFR-2), the matrix metalloproteases (MMP-2 and MMP-9), and thioredoxin reductase (TrxR1), where the complexes showed higher binding affinity in comparison to ligands, and particularly to auranofin, but comparable to sunitinib, an anti-angiogenic drug of clinical relevance.</p>