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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kostarelos, Kostas
University of Manchester
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (24/24 displayed)
- 2022Hazard Assessment of Abraded Thermoplastic Composites Reinforced with Reduced Graphene Oxidecitations
- 2021Viscoelastic surface electrode arrays to interface with viscoelastic tissuescitations
- 2020Production and processing of graphene and related materials
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materials
- 2020Production and processing of graphene and related materialscitations
- 2020Splenic Capture and In Vivo Intracellular Biodegradation of Biological-grade Graphene Oxide Sheetscitations
- 2019Enhanced Intraliposomal Metallic Nanoparticle Payload Capacity Using Microfluidic-Assisted Self-Assemblycitations
- 2018Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivitycitations
- 2015Nanocomposite hydrogels: 3D polymer-nanoparticle synergies for on-demand drug deliverycitations
- 2015Biodegradation of carbon nanohorns in macrophage cells.citations
- 2015Degradation-by-design: Surface modification with functional substrates that enhance the enzymatic degradation of carbon nanotubescitations
- 2015Nanocomposite Hydrogels: 3D Polymer-Nanoparticle Synergies for On-Demand Drug Delivery.citations
- 2015Degradation-by-design: Surface modification with functional substrates that enhance the enzymatic degradation of carbon nanotubes.citations
- 2015Degradation-by-design: Surface modification with functional substrates that enhance the enzymatic degradation of carbon nanotubes.citations
- 2015Intracellular degradation of chemically functionalized carbon nanotubes using a long-term primary microglial culture modelcitations
- 2014Biodegradation of Graphene Nanocarbons
- 2010Energy loss of protons in carbon nanotubes: experiments and calculationscitations
Places of action
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article
Hazard Assessment of Abraded Thermoplastic Composites Reinforced with Reduced Graphene Oxide
Abstract
Graphene-related materials (GRMs) are subject to intensive investigations and considerable progress has been made in recent years in terms of safety assessment. However, limited information is available concerning the hazard potential of GRM-containing products such as graphene-reinforced composites. In the present study, we conducted a comprehensive investigation of the potential biological effects of particles released through an abrasion process from reduced graphene oxide (rGO)-reinforced composites of polyamide 6 (PA6), a widely used engineered thermoplastic polymer, in comparison to as-produced rGO. First, a panel of well-established in vitro models, representative of the immune system and possible target organs such as the lungs, the gut, and the skin, was applied. Limited responses to PA6-rGO exposure were found in the different in vitro models. Only as-produced rGO induced substantial adverse effects, in particular in macrophages. Since inhalation of airborne materials is a key occupational concern, we then sought to test whether the in vitro responses noted for these materials would translate into adverse effects in vivo. To this end, the response at 1, 7 and 28 days after a single pulmonary exposure was evaluated in mice. In agreement with the in vitro data, PA6-rGO induced a modest and transient pulmonary inflammation, resolved by day 28. In contrast, rGO induced a longer-lasting, albeit moderate inflammation that did not lead to tissue remodeling within 28 days. Taken together, the present study suggests a negligible impact on human health under acute exposure conditions of GRM fillers such as rGO when released from composites at doses expected at the workplace.