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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Chen, Xi
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (20/20 displayed)
- 2024Finite‐Element Analysis of an Antagonistic Bistable Shape Memory Alloy Beam Actuator
- 2024A Methodology for Robust Multislice Ptychographycitations
- 2024Strategic Fabrication of Au4Cu2 NC/ZIF-8 Composite Via In Situ Integration Technique for Enhanced Energy Storage Applicationscitations
- 2024On the importance of the cracking process description for dynamic crack initiation simulation
- 2024In situ synthesis of oriented Zn-Mn-Co-telluride on precursor free CuOcitations
- 2024Water‐Vapor Responsive Metallo‐Peptide Nanofiberscitations
- 2024Roadmap on optical communicationscitations
- 2023Cryogenic characteristics of graphene composites—evolution from thermal conductors to thermal insulatorscitations
- 20232D Si-Ge layered materials as anodes for alkali-cation (Na+, K+) batteriescitations
- 2023Experimental and theoretical insights of binder-free magnesium nickel cobalt selenide star-like nanostructure as electrodecitations
- 2023Structural study of atomically precise doped Au38-xAgx NCs@ ZIF-8 electrode material for energy storage applicationcitations
- 2023Understanding the Diffusion-Dominated Properties of MOF-Derived Ni–Co–Se/C on CuO Scaffold Electrode using Experimental and First Principle Studycitations
- 2023Grain size in low loss superconducting Ta thin films on c axis sapphirecitations
- 2023Bistable Actuation Based on Antagonistic Buckling SMA Beamscitations
- 2022Comparative study of ternary metal chalcogenides (MX; M= Zn–Co–Ni; X= S, Se, Te)citations
- 2022Factors affecting the growth formation of nanostructures and their impact on electrode materialscitations
- 2021Binder-free trimetallic phosphate nanosheets as an electrodecitations
- 2019Nonlinear electrical conductivity through the thickness of multidirectional carbon fiber compositescitations
- 2015Peptide-functionalized zirconia and new zirconia/titanium biocermets for dental applicationscitations
- 2015Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Controlled Morphologies and High Mineral Densitycitations
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article
Peptide-functionalized zirconia and new zirconia/titanium biocermets for dental applications
Abstract
<p>Objective Titanium materials have been functionalized with biomolecules as a modern strategy to incorporate bioactive motifs that will expand and improve their biomedical applications. Here, we have biofunctionalized biomaterials based on zirconia of much interest for dentistry: the widely used bioceramic 3Y-TZP and a newly developed 3Y-TZP/Ti biocermet. Methods The biosurfaces were activated, silanized, and functionalized with coatings made of oligopeptides. Surface activation by plasma or alkaline-etching was optimized. The surfaces were coated by tethering a purposely-designed RGD-containing peptide. We selected this oligopeptide as a model peptide to validate the effectiveness of the biofunctionalization process. Successful treatments after each step of the process were assessed by surface physical and chemical characterization with water contact angles and XPS, respectively. Coatings' stability was evaluated after 2 h sonication in water. Pre-osteoblasts adhesion on the functionalized surfaces was also studied. Results 10-min air-plasma treatment effectively activated all types of materials with no detrimental effects on the material structure and hardness. Nitrogen XPS-peak confirmed that RGD-peptides were chemically-attached on the silanized samples. This was further confirmed by visualizing the functionalized surfaces with flourescence-labelled RGD-peptides before and after ultrasonication. Furthermore, RGD-functionalized surfaces significantly enhanced osteoblast adhesion on all types of substrates, which demonstrated their successful bioactivation. Conclusions We successfully developed stable functional biocoatings on zirconia and biocermets made of oligopeptides. Surface bioactivation of zirconia-containing components for dental implant applications will enable their improved clinical performance by incorporating signalling oligopeptides to accelerate osseointegration, improving permucosal sealing, and/or incorporating antimicrobial properties to prevent peri-implant infections.</p>