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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Aparicio, Conrado
Universitat Internacional de Catalunya
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (42/42 displayed)
- 2022Relevant aspects of piranha passivation in Ti6Al4V alloy dental meshescitations
- 2021Hybrid Nanocoatings of Self-assembled Organic-Inorganic Amphiphiles for Prevention of Implant Infectionscitations
- 2021Utilizing a degradation prediction pathway system to understand how a novel methacrylate derivative polymer with flipped external ester groups retains physico-mechanical properties following esterase exposurecitations
- 2020A Novel Dental Polymer with a Flipped External Ester Group Design that Resists Degradation via Polymer Backbone Preservationcitations
- 2020Physical-chemical interactions between dental materials surface, salivary pellicle and Streptococcus gordoniicitations
- 2020Harnessing biomolecules for bioinspired dental biomaterialscitations
- 2020Polymeric nanoparticles protect the resin-dentin bonded interface from cariogenic biofilm degradationcitations
- 2019Present and future of tissue engineering scaffolds for dentin-pulp complex regenerationcitations
- 2019Nano-scale modification of titanium implant surfaces to enhance osseointegrationcitations
- 2018Effects of Molecular Weight and Concentration of Poly(Acrylic Acid) on Biomimetic Mineralization of Collagencitations
- 2018In vitro cell response on CP-Ti surfaces functionalized with TGF-β1 inhibitory peptidescitations
- 2017Interfacial degradation of adhesive composite restorations mediated by oral biofilms and mechanical challenge in an extracted tooth model of secondary cariescitations
- 2015Peptide-functionalized zirconia and new zirconia/titanium biocermets for dental applicationscitations
- 2015Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Controlled Morphologies and High Mineral Densitycitations
- 2015Development of tantalum scaffold for orthopedic applications produced by space-holder methodcitations
- 2014Degradation in the dentin-composite interface subjected to multi-species biofilm challengescitations
- 2014Collagen-functionalised titanium surfaces for biological sealing of dental implantscitations
- 2014Assessing near infrared optical properties of ceramic orthodontic brackets using cross-polarization optical coherence tomographycitations
- 2013Bioactive Ceramic and Metallic Surfaces for Bone Engineeringcitations
- 2013Bioactive Ceramic and Metallic Surfaces for Bone Engineeringcitations
- 2012Imaging in vivo secondary caries and ex vivo dental biofilms using cross-polarization optical coherence tomographycitations
- 2012A reproducible oral microcosm biofilm model for testing dental materialscitations
- 2012Quantifying dental biofilm growth using cross-polarization optical coherence tomographycitations
- 2012Mineralization of peptide amphiphile nanofibers and its effect on the differentiation of human mesenchymal stem cellscitations
- 2012Biomimetic mineralization of woven bone-like nanocompositescitations
- 2011Effect of blasting treatment and Fn coating on MG63 adhesion and differentiation on titaniumcitations
- 2009Influence of the height of the external hexagon and surface treatment on fatigue life of commercially pure titanium dental implants
- 2008Oxidized NiTi surfaces enhance differentiation of osteoblast-like cellscitations
- 2007Low elastic modulus metals for joint prosthesiscitations
- 2007The influence of surface energy on competitive protein adsorption on oxidized NiTi surfacescitations
- 2007Electrochemical behaviour of oxidized NiTi shape memory alloys for biomedical applicationscitations
- 2006Bioceramics as nanomaterialscitations
- 2006Development of a biodegradable composite scaffold for bone tissue engineeringcitations
- 2006New oxidation treatment of NiTi shape memory alloys to obtain Ni-free surfaces and to improve biocompatibilitycitations
- 2005Static mechanical properties of hydroxyapatite (HA) powder-filled acrylic bone cementscitations
- 2005Surface characterization of completely degradable composite scaffoldscitations
- 2004Osseointegration of Grit-Blasted and Bioactive Titanium Implants
- 2002Effect of oxygen content on grain growth kinetics of titaniumcitations
- 2002Mechanical performance of acrylic bone cements containing different radiopacifying agentscitations
- 2002Growth of Bioactive Surfaces on Dental Implantscitations
- 2002Human-osteoblast proliferation and differentiation on grit-blasted and bioactive titanium for dental applicationscitations
- 2002Growth of bioactive surfaces on titanium and its alloys for orthopaedic and dental implantscitations
Places of action
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article
Peptide-functionalized zirconia and new zirconia/titanium biocermets for dental applications
Abstract
<p>Objective Titanium materials have been functionalized with biomolecules as a modern strategy to incorporate bioactive motifs that will expand and improve their biomedical applications. Here, we have biofunctionalized biomaterials based on zirconia of much interest for dentistry: the widely used bioceramic 3Y-TZP and a newly developed 3Y-TZP/Ti biocermet. Methods The biosurfaces were activated, silanized, and functionalized with coatings made of oligopeptides. Surface activation by plasma or alkaline-etching was optimized. The surfaces were coated by tethering a purposely-designed RGD-containing peptide. We selected this oligopeptide as a model peptide to validate the effectiveness of the biofunctionalization process. Successful treatments after each step of the process were assessed by surface physical and chemical characterization with water contact angles and XPS, respectively. Coatings' stability was evaluated after 2 h sonication in water. Pre-osteoblasts adhesion on the functionalized surfaces was also studied. Results 10-min air-plasma treatment effectively activated all types of materials with no detrimental effects on the material structure and hardness. Nitrogen XPS-peak confirmed that RGD-peptides were chemically-attached on the silanized samples. This was further confirmed by visualizing the functionalized surfaces with flourescence-labelled RGD-peptides before and after ultrasonication. Furthermore, RGD-functionalized surfaces significantly enhanced osteoblast adhesion on all types of substrates, which demonstrated their successful bioactivation. Conclusions We successfully developed stable functional biocoatings on zirconia and biocermets made of oligopeptides. Surface bioactivation of zirconia-containing components for dental implant applications will enable their improved clinical performance by incorporating signalling oligopeptides to accelerate osseointegration, improving permucosal sealing, and/or incorporating antimicrobial properties to prevent peri-implant infections.</p>