| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Morgen, Per
University of Southern Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (20/20 displayed)
- 2024Impact of drug compounds mechanical/deformation properties on the preparation of nano- and microsuspensionscitations
- 2024Impact of drug compounds mechanical/deformation properties on the preparation of nano- and microsuspensionscitations
- 2022Post-degradation case study of the membrane electrode assembly from a low-temperature PEMFC stack
- 2022Post-degradation case study of the membrane electrode assembly from a low-temperature PEMFC stack
- 2022En metode til at danne kobberlag på porøst aluminium oxid (PAO) på et substrat af aluminium legering ; A method for manufacturing copper film on porous aluminum oxide (pao) on an aluminum alloy substrate
- 2022Insights into Degradation of the Membrane–Electrode Assembly Performance in Low-Temperature PEMFC:the Catalyst, the Ionomer, or the Interface?citations
- 2022A method for manufacturing copper film on porous aluminum oxide (pao) on an aluminum alloy substrate
- 2022Insights into Degradation of the Membrane–Electrode Assembly Performance in Low-Temperature PEMFCcitations
- 2020Platinum recycling through electroless dissolution under mild conditions using a surface activation assisted Pt-complexing approachcitations
- 2020Platinum recycling through electroless dissolution under mild conditions using a surface activation assisted Pt-complexing approachcitations
- 2017Growth of aluminum oxide on silicon carbide with an atomically sharp interfacecitations
- 2016The effect of trace amounts of copper on the microstructure, stability and oxidation of macroporous silicon carbidecitations
- 2016The effect of trace amounts of copper on the microstructure, stability and oxidation of macroporous silicon carbidecitations
- 2016The role of aluminium as an additive element in the synthesis of porous 4H-silicon carbidecitations
- 2016The role of aluminium as an additive element in the synthesis of porous 4H-silicon carbidecitations
- 2015The role of Aluminium in the synthesis of Mesoporous 4H Silicon Carbide
- 2015The role of Aluminium in the synthesis of Mesoporous 4H Silicon Carbide
- 2013Investigations on sputter deposited LiCoO2 thin films from powder targetcitations
- 2009Self-activated, self-limiting reactions on Si surfaces
- 2006Epitaxial growth of Al on Si(1 1 1) with Cu buffer layerscitations
Places of action
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article
Impact of drug compounds mechanical/deformation properties on the preparation of nano- and microsuspensions
Abstract
<p>The preparation of nano- and microsuspensions used for long-acting injectables include several advantages, where the ability to control the particle sizes of a drug compound, e.g., wet bead media milling, to obtain a desired release rate, has shown to be highly critical. Limiting factors, making the formulation screening process time-consuming, are both the grindability of a compound to obtain the desired particle size profile as well as the addition of a suitable stabilizer at a sufficient concentration to secure a long-term physical stability. Hence, the deformation properties of three different model compounds (i.e., cinnarizine, haloperidol, and indomethacin) were investigated in the present study by quantifying fragmentation after tableting followed by the preparation of nano- and microsuspensions with two different stabilizers (polysorbate 20 and poloxamer 188) and concentrations (1, 2, or 4%), as well as bead size (ø 0.5 or 1.0 mm), during processing. It was found that cinnarizine had brittle properties, haloperidol predominantly plastic properties, and indomethacin elastic properties. Distinct particle size profiles, after milling by the dual centrifugation approach, were achieved for the three model compounds, when prepared under the same manufacturing conditions. It was possible to obtain decreased sizes of cinnarizine particles, whereas the grindability for haloperidol was more restricted due to its plastic properties. The study further showed that higher concentrations of poloxamer 188 were needed to obtain smaller sizes of particles when compared to polysorbate 20. Short-term stability studies showed an increase in sizes of particles over 49 days stored at elevated temperatures, especially for indomethacin suspensions stabilized with the highest polysorbate 20 concentration, due to increased solubility from the stabilizer vehicle as confirmed by a solubility study. Sizes of haloperidol particles remained relatively stable when stabilized with the highest concentration of polysorbate 20, even with increased solubility, indicating a higher physical stability as compared to cinnarizine and indomethacin.</p>