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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Pezzoli, Romina
Technological University of the Shannon: Midlands Midwest
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2023Designing Sustainable Polymer Blendscitations
- 2023Designing sustainable polymer blends: tailoring mechanical properties and degradation behaviour in PHB/PLA/PCL blends in a seawater environmentcitations
- 2020Development of sustainable flexible packaging solutions using novel biodegradable and compostable polymer blends
- 2019Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble Indomethacin with Poly(vinyl pyrrolidone-co-vinyl acetate) and polyethylene oxide.citations
- 2019Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble indomethacin with poly(vinyl pyrrolidone-co-vinyl acetate)and polyethylene oxidecitations
- 2018Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate)citations
- 2018Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate).
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article
Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble indomethacin with poly(vinyl pyrrolidone-co-vinyl acetate)and polyethylene oxide
Abstract
<p>This investigation aims to evaluate the effect of moisture and temperature on the physical stability and dissolution behaviour of hot-melt extruded binary and plasticised ternary solid dispersions. Poorly water-soluble indomethacin (IND), poly(vinyl pyrrolidone-co-vinyl acetate)(PVPVA)and plasticiser polyethylene oxide (PEO)were selected as model compounds. Extruded samples were stored with 40 °C, at 0% and 75% relative humidity (RH)for 12 weeks. Results confirmed that binary solid dispersions of PVPVA-IND were successfully prepared by twin-screw hot-melt extrusion producing amorphous single-phase systems. The inclusion of semi-crystalline PEO reduced the melt viscosity of the system acting as a processing aid during extrusion without modifying the glass transition temperature (T<sub>g</sub>)of the final doses. Samples stored at low humidity levels exhibited a dissolution profile similar to the unannealed dispersions. Samples annealed at 75% RH showed a decrease in the dissolution rate, likely related to phase separation due to the increase in molecular mobility after the water sorption. However, all the annealed samples showed a total release of IND, indicating that the dispersions were relatively stable up to 12 weeks.</p>