| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Higginbotham, Clement
Athlone Institute of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (30/30 displayed)
- 2024Response Surface Modelling Nafion-117 Sorption of Tetraammineplatinum(II) Chloride in the Electroless Plating of IPMCscitations
- 2019Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble indomethacin with poly(vinyl pyrrolidone-co-vinyl acetate)and polyethylene oxidecitations
- 2018Enhancing the bioavailability of hydrophobic drugs using hot melt extrusion
- 2018Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate)citations
- 2017Halloysite nanotube reinforced polylactic acid compositecitations
- 2016Synthesis and characterization of high density polyethylene/peat ash compositescitations
- 2016Chemical surface modification of calcium carbonate particles with stearic acid using different treating methodscitations
- 2016Melt Extruded Bioresorbable Polymer Composites for Potential Regenerative Medicine Applicationscitations
- 2016The effect of the mixing routes of biodegradable polylactic acid and polyhydroxybutyrate nanocomposites and compatibilised nanocompositescitations
- 2014The effect of processing conditions for polylactic acid based fibre composites via twin-screw extrusioncitations
- 2014Effect of Compatibilizer Content on the Mechanical Properties of Bioplastic Composites via Hot Melt Extrusioncitations
- 2014Improvement in mechanical properties of grafted polylactic acid composite fibers via hot melt extrusioncitations
- 2014Melt Processing of Bioplastic Composites via Twin Screw Extrusion and Injection Moldingcitations
- 2013Mechanical and biodegradation performance of short natural fibre polyhydroxybutyrate compositescitations
- 2011Assessing the effect of selected photoinitiators on the properties of photopolymerised temperature sensitive hydrogels
- 2011Nano-enhanced food contact materials and the in vitro toxicity to human intestinal cells of nano-ZnO at low dose
- 2011Nano-enhanced food contanct materials and the in vitro toxicity to human intestinal cells of nano-ZnO at low dose.
- 2010Physical and mechanical properties of blends based on poly (dl-lactide), poly (l-lactide-glycolide) and poly (ε-caprolactone)citations
- 2010In vitro degradation and drug release from polymer blends based on poly(dl-lactide), poly(l-lactide-glycolide) and poly(ε-caprolactone)citations
- 2010Characterisation of the effects of a titanium micro particle filler on a polyether-block-amide host matrixcitations
- 2009Development and characterisation of an agar-polyvinyl alcohol blend hydrogelcitations
- 2008Characterisation and controlled drug release from novel drug-loaded hydrogelscitations
- 2008The significance of variation in extrusion speeds and temperatures on a PEO/PCL blend based matrix for oral drug deliverycitations
- 2007The effect of salts and pH buffered solutions on the phase transition temperature and swelling of thermoresponsive pseudogels based on N-isopropylacrylamidecitations
- 2007Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion processcitations
- 2007The incorporation of an organically modified layered silicate in monolithic polymeric matrices produced using hot melt extrusioncitations
- 2007The synthesis, swelling behaviour and rheological properties of chemically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
- 2007Preparation of a novel freeze thawed poly(vinyl alcohol) composite hydrogel for drug delivery applicationscitations
- 2006The use of Agar as a novel filler for monolithic matrices produced using hot melt extrusioncitations
- 2006Lower critical solution temperature control and swelling behaviour of physically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
Places of action
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article
Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble indomethacin with poly(vinyl pyrrolidone-co-vinyl acetate)and polyethylene oxide
Abstract
<p>This investigation aims to evaluate the effect of moisture and temperature on the physical stability and dissolution behaviour of hot-melt extruded binary and plasticised ternary solid dispersions. Poorly water-soluble indomethacin (IND), poly(vinyl pyrrolidone-co-vinyl acetate)(PVPVA)and plasticiser polyethylene oxide (PEO)were selected as model compounds. Extruded samples were stored with 40 °C, at 0% and 75% relative humidity (RH)for 12 weeks. Results confirmed that binary solid dispersions of PVPVA-IND were successfully prepared by twin-screw hot-melt extrusion producing amorphous single-phase systems. The inclusion of semi-crystalline PEO reduced the melt viscosity of the system acting as a processing aid during extrusion without modifying the glass transition temperature (T<sub>g</sub>)of the final doses. Samples stored at low humidity levels exhibited a dissolution profile similar to the unannealed dispersions. Samples annealed at 75% RH showed a decrease in the dissolution rate, likely related to phase separation due to the increase in molecular mobility after the water sorption. However, all the annealed samples showed a total release of IND, indicating that the dispersions were relatively stable up to 12 weeks.</p>