| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Katsamenis, Orestis L.
University of Southampton
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 20233D printing of personalised carvedilol tablets using selective laser sinteringcitations
- 2020Fabrication of an osmotic 3D printed solid dosage form for controlled release of active pharmaceutical ingredientscitations
- 2018Controlled release of 5-Fluorouracil from alginate beads encapsulated in 3D printed pH-responsive solid dosage formscitations
- 20173D printed oral solid dosage forms containing hydrochlorothiazide for controlled drug deliverycitations
- 2017Deformation mechanisms of idealised cermets under multi-axial loadingcitations
- 2017Characterization and mapping of rolling contact fatigue in rail-axle bearingscitations
- 20153-D analysis of fatigue crack behaviour in a shot peened steam turbine blade materialcitations
- 2014Nanomechanical assessment of human and murine collagen fibrils via atomic force microscopy cantilever-based nanoindentationcitations
- 2013A novel videography method for generating crack-extension resistance curves in small bone samplescitations
- 2012Mechanism of co-nanoprecipitation of organic actives and block copolymers in a microfluidic environmentcitations
- 2012Bone matrix material properties on the micro- and nanoscale
- 2010Preparation and characterization of bioceramics produced from calcium phosphate cementscitations
Places of action
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article
3D printed oral solid dosage forms containing hydrochlorothiazide for controlled drug delivery
Abstract
3D printing has been recently employed in the design and fabrication of medicine, aiming to improve their properties and release behavior. In the current work an oral solid dosage form was designed by Fused Deposition Modeling (FDM), using a custom built filament comprised of a water soluble polymer polyvinyl alcohol (PVA), mannitol and hydrochlorothiazide (HCTZ) as model drug and further co-formulated via Hot-Melt Extrusion (HME). This composition was printed as the inner part of a three-compartment hollow cylinder dosage form using a dual extrusion 3D FDM printer, whereas the outer parts of the formulation consisted of water-insoluble polylactic acid (PLA). The produced formulations were characterized by means of differential scanning calorimetry (DSC), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). Release studies were performed in pH 1.2 and 6.8 whereas four-dimensional X-ray micro focus Computed Tomography (4D-CT), was employed to visualize volumetric and morphological changes of the formulations during the dissolution procedure. The results showed that HCTZ was incorporated in the amorphous state. Dissolution studies demonstrated that HCTZ exhibited zero-order kinetics whereas 4D-CT revealed a bi-directional smooth and homogenous reduction of PVA further corroborating the dissolution studies. The results showed that FDM printing might be used to ‘fine tune’ the release of drug molecules.