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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rahman, Muhammad Saif Ur
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (3/3 displayed)
- 2017Biocompatible waterborne polyurethane-urea elastomer as intelligent anticancer drug release matrixcitations
- 2017Sustained drug delivery of doxorubicin as a function of pH, releasing media, and NCO contents in polyurethane urea elastomerscitations
- 2017Relationship of hard segment concentration in polyurethane-urea elastomers with mechanical, thermal and drug release propertiescitations
Places of action
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article
Sustained drug delivery of doxorubicin as a function of pH, releasing media, and NCO contents in polyurethane urea elastomers
Abstract
<p>A novel diamine 4-(4-aminophenoxy)butyl-4-aminophenyl ether (ABAE) was synthesized as a chain extender (CE) by a quick and facile method using microwave reactor. CE was used for the preparation of stimuli-responsive Polyurethane-urea elastomer (PUU) with the ratio of NCO/OH from 2 to 2.5. Synthesized PUU was characterized with the help of Fourier transform infrared spectroscopy (FTIR), derivative thermogravimetric analysis (DTG), and scanning electron microscopy SEM. PUU films were loaded with an anti-cancer drug “doxorubicin”. Drug release kinetics were studied in different solvents, at different pH values and with different NCO contents of PUU. The maximum of 45% cumulative drug release was observed in DMSO while the drug release increased with the decrease in pH and a maximum cumulative release of 47% was observed at acidic pH of 4.4. The minimum drug was released from the one, which was crosslinked with highest ratio (2.5) of NCO/OH. So, we can say that drug release can easily be adjusted under different conditions and environments with the help of these stimuli-responsive media.</p>