| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zia, Abdul Wasy
Heriot-Watt University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2024Innovative Tin and hard carbon architecture for enhanced stability in lithium-ion battery anodescitations
- 2024Sputtered Hard Carbon for High-Performance Energy Storage Batteries
- 2024Designing Molybdenum Trioxide and Hard Carbon Architecture for Stable Lithium‐Ion Battery Anodescitations
- 2024Wear-resistant and adherent nanodiamond composite thin film for durable and sustainable silicon carbide mechanical seals.citations
- 2024Circular usage of waste cooking oil towards green electrical discharge machining process with lower carbon emissionscitations
- 2024Oxygen concentration – a governing parameter for microstructural tailoring of duplex AlCrSiON coatings for superior mechanical, tribological, and anti-corrosion performancecitations
- 2024Wear-resistant and Adherent Nanodiamond Composite Thin Film for Durable and Sustainable Silicon Carbide Mechanical Sealscitations
- 2024Role of scandium addition to microstructure, corrosion resistance, and mechanical properties of AA7085/ZrB2+Al2O3 compositescitations
- 2024Precision depth-controlled isolated silver nanoparticle-doped diamond-like carbon coatings with enhanced ion release, biocompatibility, and mechanical performancecitations
- 2023Soft diamond-like carbon coatings with superior biocompatibility for medical applicationscitations
- 2023Multi-layered Sn and Hard Carbon Architectures for Long-Term Stability and High-Capacity Lithium-Ion Battery Anodes
- 2023Role of biodegradable dielectrics toward tool wear and dimensional accuracy in Cu-mixed die sinking EDM of Inconel 600 for sustainable machiningcitations
- 2023Role of biodegradable dielectrics toward tool wear and dimensional accuracy in Cu-mixed die sinking EDM of Inconel 600 for sustainable machining
- 2023Advancing Lithium-Ion Battery Anodes: Novel Sn and Hard Carbon Architectures for Long-Term Stability and High Capacity
- 2022Disrupting biofilm and eradicating bacteria by Ag-Fe3O4@MoS2 MNPs nanocomposite carrying enzyme and antibioticscitations
- 2013Epitaxial growth of cerium oxide thin films by pulsed laser depositioncitations
- 2013Effect of Diamond like Carbon Coating Thickness on Stainless Steel Substrate
- 2012 Fracture Toughness of Plasma Coated Zirconia(ZrO₂)
- 2012Mechanical Characterization of PECVD coated Materials by Indentation Techniques and Finite Element Simulation
Places of action
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article
Disrupting biofilm and eradicating bacteria by Ag-Fe3O4@MoS2 MNPs nanocomposite carrying enzyme and antibiotics
Abstract
<p>In this study, novel multilayered magnetic nanoparticles (ML-MNPs) loaded with DNase and/or vancomycin (Vanc) were fabricated for eliminating multispecies biofilms. Iron-oxide MNPs (IO-core) (500–800 nm) were synthesized via co-precipitation; further, the IO-core was coated with heavy-metal-based layers (Ag and MoS<sub>2</sub> NPs) using solvent evaporation. DNase and Vanc were loaded onto the outermost layer of the ML-MNP formed by nanoporous MoS<sub>2</sub> NPs through physical deposition and adsorption. The biofilms of S. mutans or E. faecalis (or both) were formed in a brain-heart-infusion broth (BHI) for 3 days, followed by treatment with ML-MNPs for 24 h. The results revealed that coatings of Ag (200 nm) and ultrasmall MoS<sub>2</sub> (20 nm) were assembled as outer layers of ML-MNPs successfully, and they formed Ag-Fe<sub>3</sub>O<sub>4</sub>@MoS<sub>2</sub> MNPs (3–5 μm). The DNase-Vanc-loaded MNPs caused nanochannels digging and resulted in the enhanced penetration of MNPs towards the bottom layers of biofilm, which resulted in a decrease in the thickness of the 72-h biofilm from 48 to 58 μm to 0–4 μm. The sustained release of Vanc caused a synergistic bacterial killing up to 96%–100%. The heavy-metal-based layers of MNPs act as nanozymes to interfere with bacterial metabolism and proliferation, which adversely affects biofilm integrity. Further, loading DNase/Vanc onto the nanoporous-MoS<sub>2</sub>-layer of ML-MNPs promoted nanochannel creation through the biofilm. Therefore, DNase-and Vanc-loaded ML-MNPs exhibited potent effects on biofilm disruption and bacterial killing.</p>