| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Schumacher, Matthias
Maastricht University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2023Mesoporous Bioactive Glass-Incorporated Injectable Strontium-Containing Calcium Phosphate Cement Enhanced Osteoconductivity in a Critical-Sized Metaphyseal Defect in Osteoporotic Ratscitations
- 2022Zn-Loaded and Calcium Phosphate-Coated Degradable Silica Nanoparticles Can Effectively Promote Osteogenesis in Human Mesenchymal Stem Cellscitations
- 2022Functionalization of Ti-40Nb implant material with strontium by reactive sputtering
- 2021Cobalt-containing calcium phosphate induces resorption of biomineralized collagen by human osteoclastscitations
- 2020Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materialscitations
- 2020Electrodeposition of Sr-substituted hydroxyapatite on low modulus beta-type Ti-45Nb and effect on in vitro Sr release and cell responsecitations
- 2019Investigation of strontium transport and strontium quantification in cortical rat bone by time-of-flight secondary ion mass spectrometrycitations
- 2019Electrodeposition of Sr-substituted hydroxyapatite on low modulus beta-type Ti-45Nb and effect on in vitro Sr release and cell response
- 2018Strontium-modification of porous scaffolds from mineralized collagen for potential use in bone defect therapycitations
- 2017Strontium release from Sr2+-loaded bone cements and dispersion in healthy and osteoporotic rat bonecitations
- 2017Functionalization of Ti-40Nb implant material with strontium by reactive sputteringcitations
Places of action
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article
Strontium release from Sr2+-loaded bone cements and dispersion in healthy and osteoporotic rat bone
Abstract
<p>Drug functionalization of biomaterials is a modern and popular approach in biomaterials research. Amongst others this concept is used for the functionalization of bone implants to locally stimulate the bone healing process. For example strontium ions (Sr<sup>2+</sup>) are administered in osteoporosis therapy to stimulate bone growth and have recently been integrated into bone cements. Based on results of different analytical experiments we developed a two-phase model for the transport of therapeutically active Sr<sup>2+</sup>-ions in bone in combination with Korsmeyer-Peppas kinetics for the Sr<sup>2+</sup> release from bone cement. Data of cement dissolution experiments into water in combination with inductively coupled plasma mass spectrometry (ICP-MS) analysis account for dissolution kinetics following Noyes-Whitney rule. For dissolution in α-MEM cell culture media the process is kinetically hindered and can be described by Korsmeyer-Peppas kinetics. Time of flight secondary ion mass spectrometry (ToF-SIMS) was used to determine the Sr<sup>2+</sup> diffusion coefficient in healthy and osteoporotic trabecular rat bone. Therefore, bone sections were dipped in aqueous Sr<sup>2+</sup>-solution by one side and the Sr<sup>2+</sup>-profile was measured by classical SIMS depth profiling. The Sr<sup>2+</sup> mobility can be described by a simple diffusion model and we obtained diffusion coefficients of (2.28 ± 2.97) ⋅ 10<sup>− 12</sup> cm<sup>2</sup>/s for healthy and of (1.55 ± 0.93) ⋅ 10<sup>− 10</sup> cm<sup>2</sup>/s for osteoporotic bone. This finding can be explained by a different bone nanostructure, which was observed by focused ion beam scanning electron microscopy (FIB-SEM) and transmission electron microscopy (TEM). Finally, the time and spatially resolved drug transport was calculated by finite element method for the femur of healthy and osteoporotic rats. The obtained results were compared to mass images that were obtained from sections of in vivo experiments by ToF-SIMS. The simulated data fits quite well to experimental results. The successfully applied model for the description of drug dispersion can help to reduce the number of animal experiments in the future.</p>