Materials Map

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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Frijlink, Henderik W.

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University of Groningen

in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (32/32 displayed)

  • 2024Combinations of arginine and pullulan reveal the selective effect of stabilization mechanisms on different lyophilized proteins1citations
  • 2018The mechanism behind the biphasic pulsatile drug release from physically mixed poly(DL-lactic(-co-glycolic) acid)-based compacts17citations
  • 2018The mechanism behind the biphasic pulsatile drug release from physically mixed poly(DL-lactic(-co-glycolic) acid)-based compacts17citations
  • 2017Dry powder inhalation236citations
  • 2017Increased drug load and polymer compatibility of bilayered orodispersible films41citations
  • 2016Compacted Solid Dosage Formcitations
  • 2016Single dose sublingual testosterone and oral sildenafil versus a dual-route/dual-release fixed-dose combination tablet13citations
  • 2015Protein release from water-swellable poly(d,l-lactide-PEG)-b-poly(ϵ-caprolactone) implants9citations
  • 2015Protein Stability during Hot Melt Extrusioncitations
  • 2015Size and molecular flexibility of sugars determine the storage stability of freeze-dried proteins120citations
  • 2015Protein Stability during Hot Melt Extrusion: The Effect of Extrusion Temperature, Hydrophilicity of Polymers and Sugar Glass Pre-stabilizationcitations
  • 2015Polymeric formulations for drug release prepared by hot melt extrusion:application and characterization107citations
  • 2015Polymeric formulations for drug release prepared by hot melt extrusion107citations
  • 2014Pharmacokinetics of a Prototype Formulation of Sublingual Testosterone and a Buspirone Tablet, Versus an Advanced Combination Tablet of Testosterone and Buspirone in Healthy Premenopausal Women15citations
  • 2013Unraveling protein stabilization mechanisms151citations
  • 2012Preparation and physicochemical evaluation of a new tacrolimus tablet formulation for sublingual administration13citations
  • 2010Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets24citations
  • 2008Pore shape in the sodium chloride matrix of tablets after the addition of starch as a second component3citations
  • 2008Pore shape in the sodium chloride matrix of tablets after the addition of starch as a second component3citations
  • 2008Using the internal stress concept to assess the importance of moisture sorption-induced swelling on the moisture transport through the glassy HPMC films4citations
  • 2006Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques130citations
  • 2005Inulin is a promising cryo- and lyoprotectant for PEGylated lipoplexes73citations
  • 2005The effect of powder blend and tablet structure on drug release mechanisms of hydrophobic starch acetate matrix tablets29citations
  • 2005Location-dependent analysis of porosity and pore direction in tablets10citations
  • 2005Location-dependent analysis of porosity and pore direction in tablets10citations
  • 2004Pulmonary delivery of therapeutic peptides via dry powder inhalation67citations
  • 2004Incorporation of lipophilic drugs in sugar glasses by lyophilization using a mixture of water and tertiary butyl alcohol as solvent66citations
  • 2003Investigations into the stabilization of drugs by sugar glasses31citations
  • 2003Investigations into the stabilization of drugs by sugar glasses:III. The influence of various high-pH buffers31citations
  • 2001Plasticisation of amylodextrin by moisture. Consequences for compaction behaviour and tablet properties34citations
  • 2001Inulin glasses for the stabilization of therapeutic proteins156citations
  • 2001Effect of molecular weight and glass transition on relaxation and release behaviour of poly(DL-lactic acid) tablets64citations

Places of action

Chart of shared publication
Lasorsa, Alessia
1 / 1 shared
Hinrichs, Wouter
16 / 17 shared
Nguyen, Trung Truong Khanh
1 / 1 shared
Zillen, Daan
1 / 2 shared
Grasmeijer, Niels
3 / 3 shared
Beugeling, Max
2 / 2 shared
Born, Philip A.
2 / 2 shared
Amssoms, Katie
2 / 2 shared
Baert, Lieven
2 / 2 shared
Hinrichs, Wouter L. J.
3 / 3 shared
Schwengle, Kevin
2 / 2 shared
Meulen, Merel Van Der
1 / 1 shared
Grasmeijer, Floris
1 / 1 shared
Hagedoorn, P.
1 / 1 shared
Boer, Anne De
1 / 1 shared
Buttini, F.
1 / 2 shared
Hoppentocht, M.
1 / 1 shared
Weggemans, Oekie A. F.
1 / 1 shared
Visser, J. Carolina
1 / 1 shared
Boosman, Rene J.
1 / 1 shared
Loos, Katja U.
1 / 56 shared
Woerdenbag, Herman J.
1 / 1 shared
Amssoms, Katie Ingrid Eduard
1 / 1 shared
Baert, Lieven Elvire Colette
1 / 1 shared
Koppeschaar, H. P. F.
1 / 1 shared
Olivier, B.
1 / 1 shared
Tuiten, A.
1 / 1 shared
Bloemers, J.
1 / 1 shared
Rooij, K. Van
1 / 1 shared
Leede, L. De
1 / 1 shared
Zuidema, Johan
1 / 1 shared
Steendam, Rob
1 / 1 shared
Hiemstra, Christine
1 / 1 shared
Waard, Hans De
1 / 1 shared
Stanković, Milica
3 / 3 shared
Olinga, Peter
2 / 2 shared
Teekamp, Naomi
2 / 2 shared
Tonnis, W. F.
1 / 1 shared
Mensink, M. A.
1 / 1 shared
Jager, A. De
1 / 1 shared
Poels, Saskia
1 / 1 shared
Koppeschaar, Hans
1 / 1 shared
Bloemers, Jos
1 / 1 shared
Olivier, Berend
1 / 1 shared
Tuiten, Adriaan
1 / 1 shared
Rooij, Kim Van
1 / 1 shared
Leede, Leo De
1 / 1 shared
Stankovic, M.
1 / 1 shared
Waard, H. De
1 / 1 shared
Grasmeijer, N.
1 / 1 shared
Pham, Bao T.
1 / 1 shared
Holen, Maru
1 / 1 shared
Plas, Afke Van Der
1 / 1 shared
Schellekens, Reinout C. A.
1 / 1 shared
Srinarong, Parinda
2 / 2 shared
Visser, Marinella R.
1 / 1 shared
Kouwen, Sander
1 / 1 shared
Vliet, Lucas J. Van
2 / 2 shared
Wu, Yu San
4 / 4 shared
Van Vliet, Lucas J.
2 / 2 shared
Vromans, Herman
1 / 5 shared
Kok, Paul J. A. Hartman
1 / 1 shared
Laksmana, Fesia L.
1 / 1 shared
Visser, M. R.
1 / 1 shared
Drooge, D. J. Van
2 / 2 shared
Smedt, S. C. De
1 / 1 shared
Sanders, N. N.
1 / 1 shared
Demeester, J.
1 / 2 shared
Ketolainen, J.
1 / 2 shared
Veen, B. Van
1 / 1 shared
Poso, A.
1 / 2 shared
Pajander, J.
1 / 2 shared
Lappalainen, R.
1 / 8 shared
Zuurman, K.
1 / 2 shared
Stokroos, Ietse
2 / 3 shared
Goede, J.
1 / 2 shared
Irngartinger, M.
1 / 2 shared
Damm, M.
1 / 2 shared
Camuglia, V.
1 / 2 shared
Jong, Gerhardus J. De
1 / 1 shared
Somsen, Govert W.
2 / 3 shared
Eriksson, Jonas H. C.
2 / 2 shared
De Jong, Gerhardus J.
1 / 1 shared
Steendam, R.
2 / 2 shared
Lerk, C. F.
2 / 2 shared
Prinsen, M. G.
1 / 1 shared
Hennink, W. E.
1 / 5 shared
Steenbergen, M. J. Van
1 / 1 shared
Chart of publication period
2024
2018
2017
2016
2015
2014
2013
2012
2010
2008
2006
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2004
2003
2001

Co-Authors (by relevance)

  • Lasorsa, Alessia
  • Hinrichs, Wouter
  • Nguyen, Trung Truong Khanh
  • Zillen, Daan
  • Grasmeijer, Niels
  • Beugeling, Max
  • Born, Philip A.
  • Amssoms, Katie
  • Baert, Lieven
  • Hinrichs, Wouter L. J.
  • Schwengle, Kevin
  • Meulen, Merel Van Der
  • Grasmeijer, Floris
  • Hagedoorn, P.
  • Boer, Anne De
  • Buttini, F.
  • Hoppentocht, M.
  • Weggemans, Oekie A. F.
  • Visser, J. Carolina
  • Boosman, Rene J.
  • Loos, Katja U.
  • Woerdenbag, Herman J.
  • Amssoms, Katie Ingrid Eduard
  • Baert, Lieven Elvire Colette
  • Koppeschaar, H. P. F.
  • Olivier, B.
  • Tuiten, A.
  • Bloemers, J.
  • Rooij, K. Van
  • Leede, L. De
  • Zuidema, Johan
  • Steendam, Rob
  • Hiemstra, Christine
  • Waard, Hans De
  • Stanković, Milica
  • Olinga, Peter
  • Teekamp, Naomi
  • Tonnis, W. F.
  • Mensink, M. A.
  • Jager, A. De
  • Poels, Saskia
  • Koppeschaar, Hans
  • Bloemers, Jos
  • Olivier, Berend
  • Tuiten, Adriaan
  • Rooij, Kim Van
  • Leede, Leo De
  • Stankovic, M.
  • Waard, H. De
  • Grasmeijer, N.
  • Pham, Bao T.
  • Holen, Maru
  • Plas, Afke Van Der
  • Schellekens, Reinout C. A.
  • Srinarong, Parinda
  • Visser, Marinella R.
  • Kouwen, Sander
  • Vliet, Lucas J. Van
  • Wu, Yu San
  • Van Vliet, Lucas J.
  • Vromans, Herman
  • Kok, Paul J. A. Hartman
  • Laksmana, Fesia L.
  • Visser, M. R.
  • Drooge, D. J. Van
  • Smedt, S. C. De
  • Sanders, N. N.
  • Demeester, J.
  • Ketolainen, J.
  • Veen, B. Van
  • Poso, A.
  • Pajander, J.
  • Lappalainen, R.
  • Zuurman, K.
  • Stokroos, Ietse
  • Goede, J.
  • Irngartinger, M.
  • Damm, M.
  • Camuglia, V.
  • Jong, Gerhardus J. De
  • Somsen, Govert W.
  • Eriksson, Jonas H. C.
  • De Jong, Gerhardus J.
  • Steendam, R.
  • Lerk, C. F.
  • Prinsen, M. G.
  • Hennink, W. E.
  • Steenbergen, M. J. Van
OrganizationsLocationPeople

article

Inulin is a promising cryo- and lyoprotectant for PEGylated lipoplexes

  • Smedt, S. C. De
  • Frijlink, Henderik W.
  • Sanders, N. N.
  • Hinrichs, Wouter
  • Demeester, J.
Abstract

<p>The aim of this study was to investigate whether the oligosaccharides dextran and inulin are able to prevent aggregation of lipoplexes based on 1,2-dioleoyl-3-trimethylammonium-propane and dioleoylphosphatidyl-ethanolamine with and without distearoylphosphatidylethanolamine-polyethyleneglycol (PEGylated and nonPEGylated lipoplexes, respectively) during storage. The lipoplexes, dispersed in the oligosaccharide solution were frozen and subsequently stored at subzero temperature or freeze dried and subsequently stored at 37 degrees C. When lipoplexes in frozen dispersions were stored below the glass transition temperature of the maximally freeze concentrated fraction (Tg') of the oligosaccharide solutions severe aggregation of the nonPEGylated lipoplexes was prevented for 3 months by both inulin and dextran. However, while dextran failed to stabilize the frozen PEGylated lipoplexes (as in most cases full aggregation occurred in short time) inulin successfully protected them against aggregation. Compared to dextran, inulin was also a superior lyoprotectant of PEGylated lipoplexes: during freeze drying and subsequent storage at 37 degrees C of the dried powders for 3 months the PEGylated lipoplexes maintained their original size when dispersed in inulin matrices while in dextran matrices they fully aggregated in most cases. It is hypothesized that the aggregation of the PEGylated lipoplexes in dextran solutions is caused by the well known incompatibility between dextrans and PEG. This is further supported by the observation that inulins and PEG are compatible. It is concluded that oligosaccharides can prevent severe aggregation of nonPEGylated lipoplexes. The same holds for PEGylated lipoplexes provided that the oligosaccharide is compatible with PEG. Finally, this work also shows that the higher Tg' of oligosaccharides makes them more versatile cryoprotectants than disaccharides like sucrose or trehalose as the frozen dispersions can be stored at higher temperatures for prolonged periods of time. Furthermore, it is proposed that oligosaccharides are also more versatile lyoprotectants than the disaccharides because they can be exposed to higher relative humidities without passing the glass transition temperature. (c) 2004 Elsevier B.V. All rights reserved.</p>

Topics
  • impedance spectroscopy
  • dispersion
  • glass
  • glass
  • thermogravimetry
  • glass transition temperature
  • drying