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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Witek, Lukasz
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (42/42 displayed)
- 20233D Printing Type 1 Bovine Collagen Scaffolds for Tissue Engineering Applications—Physicochemical Characterization and In Vitro Evaluationcitations
- 2023Engineering 3D Printed Bioceramic Scaffolds to Reconstruct Critical-Sized Calvaria Defects in a Skeletally Immature Pig Modelcitations
- 2023Three-Dimensional Printing Bioceramic Scaffolds Using Direct-Ink-Writing for Craniomaxillofacial Bone Regeneration. citations
- 2022Residual stress estimated by nanoindentation in pontics and abutments of veneered zirconia fixed dental prosthesescitations
- 2022Physiochemical and bactericidal activity evaluationcitations
- 2022Temporary materials used in prosthodonticscitations
- 2022Stability of fatigued and aged ZTA compared to 3Y-TZP and Al2O3 ceramic systemscitations
- 2021Three-Dimensionally-Printed Bioactive Ceramic Scaffoldscitations
- 2021Nanoscale physico-mechanical properties of an aging resistant ZTA compositecitations
- 2021Effect of supplemental acid-etching on the early stages of osseointegrationcitations
- 2021Hydrothermal aging affects the three-dimensional fit and fatigue lifetime of zirconia abutmentscitations
- 2020Comparative analysis of elastomeric die materials for semidirect composite restorations.
- 2020Bone Tissue Engineering in the Growing Calvaria Using Dipyridamole-Coated, Three-Dimensionally-Printed Bioceramic Scaffoldscitations
- 2020Comparative analysis of elastomeric die materials for semidirect composite restorations
- 2020Microstructural, mechanical, and optical characterization of an experimental aging-resistant zirconia-toughened alumina (ZTA) compositecitations
- 2020Assessing osseointegration of metallic implants with boronized surface treatmentcitations
- 2020Aging resistant ZTA composite for dental applicationscitations
- 2019Long-term outcomes of 3D-printed bioactive ceramic scaffolds for regeneration of the pediatric skeleton
- 2019Osteointegrative and microgeometric comparison between micro-blasted and alumina blasting/acid etching on grade II and V titanium alloys (Ti-6Al-4V)citations
- 2019Physical and chemical characterization of synthetic bone mineral ink for robocasting applications
- 2019Dipyridamole Augments Three-Dimensionally Printed Bioactive Ceramic Scaffolds to Regenerate Craniofacial Bonecitations
- 2019Tissue-engineered alloplastic scaffolds for reconstruction of alveolar defectscitations
- 2019Comparative in vitro study of 3D robocasting scaffolds using beta tricalcium phosphate and synthetic bone mineral
- 2019Synergistic effects of implant macrogeometry and surface physicochemical modifications on osseointegrationcitations
- 2019Repair of Critical-Sized Long Bone Defects Using Dipyridamole-Augmented 3D-Printed Bioactive Ceramic Scaffoldscitations
- 2019Nanomechanical and microstructural characterization of a zirconia-toughened alumina composite after agingcitations
- 2019Dipyridamole-loaded 3D-printed bioceramic scaffolds stimulate pediatric bone regeneration in vivo without disruption of craniofacial growth through facial maturitycitations
- 2019Regeneration of a Pediatric Alveolar Cleft Model Using Three-Dimensionally Printed Bioceramic Scaffolds and Osteogenic Agentscitations
- 2018Form and functional repair of long bone using 3D-printed bioactive scaffoldscitations
- 2018Dipyridamole enhances osteogenesis of three-dimensionally printed bioactive ceramic scaffolds in calvarial defectscitations
- 2018Three dimensionally printed bioactive ceramic scaffold osseoconduction across critical-sized mandibular defectscitations
- 2017Controlling calcium and phosphate ion release of 3D printed bioactive ceramic scaffoldscitations
- 2017Biocompatibility and degradation properties of WE43 Mg alloys with and without heat treatmentcitations
- 2017Abstract 47. Dipyridamole-Containing 3D-Printed Bioactive Ceramic Scaffolds for the Treatment of Calvarial Defects
- 2015Geometrical versus Random beta-TCP Scaffolds: Exploring the Effects on Schwann Cell Growth and Behaviorcitations
- 2014The physicochemical characterization and in vivo response of micro/nanoporous bioactive ceramic particulate bone graft materialscitations
- 2014The in vivo effect of P-15 coating on early osseointegrationcitations
- 2013MicroCT analysis of a retrieved root restored with a bonded fiber-reinforced composite dowelcitations
- 2012Physicochemical characterization and in vivo evaluation of amorphous and partially crystalline calcium phosphate coatings fabricated on Ti-6Al-4V implants by the plasma spray methodcitations
- 2012Abutment Design for Implant-Supported Indirect Composite Molar Crownscitations
- 2012Characterization and in vivo evaluation of laser sintered dental endosseous implants in dogscitations
- 2011Additive CAD/CAM process for dental prosthesescitations
Places of action
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article
Dipyridamole enhances osteogenesis of three-dimensionally printed bioactive ceramic scaffolds in calvarial defects
Abstract
<p>Purpose: The objective of this study was to test the osteogenic capacity of dipyridamole-loaded, three-dimensionally printed, bioactive ceramic (3DPBC) scaffolds using a translational, skeletally mature, large-animal calvarial defect model. Materials and methods: Custom 3DPBC scaffolds designed to present lattice-based porosity only towards the dural surface were either coated with collagen (control) or coated with collagen and immersed in a 100 μM concentration dipyridamole (DIPY) solution. Sheep (n = 5) were subjected to 2 ipsilateral trephine-induced (11-mm diameter) calvarial defects. Either a control or a DIPY scaffold was placed in each defect, and the surgery was repeated on the contralateral side 3 weeks later. Following sacrifice, defects were evaluated through microcomputed tomography and histologic analysis for bone, scaffold, and soft tissue quantification throughout the defect. Parametric and non-parametric methods were used to determine statistical significance based on data distribution. Results: No exuberant or ectopic bone formation was observed, and no histologic evidence of inflammation was noted within the defects. Osteogenesis was higher in DIPY-coated scaffolds compared to controls at 3 weeks (p = 0.013) and 6 weeks (p = 0.046) in vivo. When bone formation was evaluated as a function of defect radius, average bone formation was higher for DIPY relative to control scaffolds at both time points (significant at defect central regions at 3 weeks and at margins at 6 weeks, p = 0.046 and p = 0.031, respectively). Conclusion: Dipyridamole significantly improves the calvarial bone regeneration capacity of 3DPBC scaffolds. The most significant difference in bone regeneration was observed centrally within the interface between the 3DPBC scaffold and the dura mater.</p>