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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Glasius, Marianne
Aarhus University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (4/4 displayed)
- 2018Rapid Determination of Water, Total Acid Number, and Phenolic Content in Bio-Crude from Hydrothermal Liquefaction of Biomass using FT-IRcitations
- 2017Synthesis and characterization of O-acylated-ω-hydroxy fatty acids as skin-protecting barrier lipidscitations
- 2016Ultralong Fatty Acyl Derivatives As Occlusive Structure Lipids for Cosmetic Applicationscitations
- 2016Ultralong Fatty Acyl Derivatives As Occlusive Structure Lipids for Cosmetic Applications:Synthesis and Characterizationcitations
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article
Synthesis and characterization of O-acylated-ω-hydroxy fatty acids as skin-protecting barrier lipids
Abstract
<p>A series of O-acylated-ω-hydroxy fatty acids (Acyl acids) of up to 34 carbons were synthesized and characterized through DSC, FTIR and Langmuir isotherm measurements to identify potential replacements to petrolatum, a highly used occlusive technology that if unrefined, it can potentially be classified as carcinogenic. Fourier transform infrared spectroscopy studies demonstrated that long acyl acids engender orthorhombic packing; packing behavior that is predominant in the lipid matrix of healthy stratum corneum, the outmost layer of the skin. In addition, Differential Scanning Calorimetry (DSC) and Langmuir isotherm studies suggested that the length of the hydrocarbon chain and the position of the ester bond influence the molecular organization of the acyl acids. For instance, 16-(tetradecanoyloxy)hexadecanoic acid (30 carbons) displayed a higher melting point (mp = 68 °C) than 10-(stearoyloxy)decanoic acid (28 carbons; mp = 63 °C) and 10-(tetradecanoyloxy)decanoic acid (24 carbons; mp = 55 °C) according to DSC. Moreover, Langmuir isotherm studies showed that mixtures of acyl acid with distearoylphosphatidylcholine improved packing behavior. Finally, Water Vapor Transmission Rate (WVTR) measurements showed that the compounds in fact decrease WVTR compared to untreated control (P < 0.001) which demonstrates the potential of these ingredients as occlusive technologies to combat skin barrier diseases.</p>