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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Dong, Mingdong
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Topics
Publications (8/8 displayed)
- 2022Antimicrobial and Wound-Healing Activities of Graphene-Reinforced Electrospun Chitosan/Gelatin Nanofibrous Nanocomposite Scaffoldscitations
- 2017Synthesis and characterization of O-acylated-ω-hydroxy fatty acids as skin-protecting barrier lipidscitations
- 2016Ultralong Fatty Acyl Derivatives As Occlusive Structure Lipids for Cosmetic Applicationscitations
- 2014$mathrm{(NH_{4})_{4}Sn_{2}S_{6}·3H_{2}O}$: Crystal Structure, Thermal Decomposition, and Precursor for Textured Thin Filmcitations
- 2013Electrospun UV-responsive supramolecular nanofibers from a cyclodextrin-azobenzene inclusion complexcitations
- 2010Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowthcitations
- 2010DNA-templated covalent coupling of G4 PAMAM dendrimerscitations
- 2009Self-assembly of a nanoscale DNA box with a controllable lidcitations
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article
Synthesis and characterization of O-acylated-ω-hydroxy fatty acids as skin-protecting barrier lipids
Abstract
<p>A series of O-acylated-ω-hydroxy fatty acids (Acyl acids) of up to 34 carbons were synthesized and characterized through DSC, FTIR and Langmuir isotherm measurements to identify potential replacements to petrolatum, a highly used occlusive technology that if unrefined, it can potentially be classified as carcinogenic. Fourier transform infrared spectroscopy studies demonstrated that long acyl acids engender orthorhombic packing; packing behavior that is predominant in the lipid matrix of healthy stratum corneum, the outmost layer of the skin. In addition, Differential Scanning Calorimetry (DSC) and Langmuir isotherm studies suggested that the length of the hydrocarbon chain and the position of the ester bond influence the molecular organization of the acyl acids. For instance, 16-(tetradecanoyloxy)hexadecanoic acid (30 carbons) displayed a higher melting point (mp = 68 °C) than 10-(stearoyloxy)decanoic acid (28 carbons; mp = 63 °C) and 10-(tetradecanoyloxy)decanoic acid (24 carbons; mp = 55 °C) according to DSC. Moreover, Langmuir isotherm studies showed that mixtures of acyl acid with distearoylphosphatidylcholine improved packing behavior. Finally, Water Vapor Transmission Rate (WVTR) measurements showed that the compounds in fact decrease WVTR compared to untreated control (P < 0.001) which demonstrates the potential of these ingredients as occlusive technologies to combat skin barrier diseases.</p>