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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Hill, Martyn
University of Southampton
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2021Surface temperature condition monitoring methods for aerospace turbomachinery: exploring the use of ultrasonic guided wavescitations
- 2019Acoustofluidic particle steeringcitations
- 2014Acoustic devices for particle and cell manipulation and sensingcitations
- 2013The effect of ultrasound-related stimuli on cell viability in microfluidic channelscitations
- 2013Planar particle trapping and manipulation with ultrasonic transducer arrays
- 2012Mechanism of co-nanoprecipitation of organic actives and block copolymers in a microfluidic environmentcitations
- 2011Continuous-flow production of polymeric micelles in microreactors: experimental and computational analysiscitations
- 2008Performance of a quarter-wavelength particle concentratorcitations
- 2007Microfluidic system for cell transfection using sonoporation and ultrasonic particle manipulation
- 2004Acoustic power output measurements for thick-film PZT transducerscitations
- 2004An ultrasonic transducer array for velocity measurement in underwater vehiclescitations
Places of action
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article
Continuous-flow production of polymeric micelles in microreactors: experimental and computational analysis
Abstract
We report the development of a microfluidic-based process for the production of polymeric micelles (PMs) in continuous-flow microreactors where Pluronic® tri-block copolymer is used as model polymeric biomaterial relating to drug delivery applications. A flow focusing configuration is used enabling a controllable, and fast mixing process to assist the formation of polymeric micelles through nanoprecipitation which is triggered by a solvent exchange process when organic solutions of the polymer mixed with a non-solvent. We experientially investigate the effect of polymer concentration, flow rate ratio and microreactor dimension on the PMs size characteristics. The mixing process within the microfluidic reactors is further analyzed by computational modeling in order to understand the hydrodynamic process and its implication for the polymeric micells formation process. The results obtained show that besides the effect of the flow rate ratio, the chemical environment in which the aggregation takes place plays an important role in determining the dimensional characteristics of the produced polymeric micelles. It is demonstrated that microfluidic reactors provide a useful platform for the continuous-flow production of polymeric micelles with improved controllability, reproducibility, and homogeneity of the size characteristics.