Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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693.932 PEOPLE
693.932 People People

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University of Manchester

in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (6/6 displayed)

  • 2022Hydroxyapatite-decorated Fmoc-hydrogel as a bone-mimicking substrate for osteoclast differentiation and culture28citations
  • 2020Exploiting the role of nanoparticle shape in enhancing hydrogel adhesive and mechanical properties234citations
  • 2014Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs137citations
  • 2010Thermally-triggered gelation of PLGA dispersions: Towards an injectable colloidal cell delivery system30citations
  • 2010Thermally-triggered gelation of PLGA dispersions: Towards an injectable colloidal cell delivery system30citations
  • 2009Introducing chemical functionality in Fmoc-peptide gels for cell culture286citations

Places of action

Chart of shared publication
Hodson, Nigel
2 / 7 shared
Ligorio, Cosimo
1 / 2 shared
Bella, Jordi
1 / 1 shared
Hoyland, Judith A.
4 / 6 shared
Vitale, Mattia
1 / 1 shared
Mcavan, Bethan
1 / 1 shared
Allan, Chris
1 / 1 shared
Oreilly, Rachel K.
1 / 10 shared
Li, Zehua
1 / 3 shared
Binch, Abbie L. A.
1 / 1 shared
Arno, Maria C.
1 / 1 shared
Platt, Christopher I.
1 / 1 shared
Inam, Maria
1 / 2 shared
Weems, Andrew C.
1 / 1 shared
Dove, Andrew P.
1 / 3 shared
Mcconnell, James C.
1 / 1 shared
Clarke, Louise E.
1 / 1 shared
Sherratt, Michael J.
1 / 7 shared
Derby, Brian
1 / 45 shared
Liu, Ruixue
2 / 5 shared
Fraylich, Michael R.
2 / 2 shared
Saunders, Brian R.
2 / 35 shared
Shakesheff, Kevin
2 / 3 shared
Baird, Pauline
2 / 2 shared
Alexander, Cameron
2 / 14 shared
Freemont, Tony J.
1 / 5 shared
Cellesi, Francesco
2 / 8 shared
Freemont, Anthony J.
1 / 1 shared
Hoyland, Judith
1 / 2 shared
Gough, Julie
1 / 7 shared
Ulijn, Rein V.
1 / 8 shared
Hirst, Andrew R.
1 / 1 shared
Saiani, Alberto
1 / 9 shared
Jayawarna, Vineetha
1 / 2 shared
Chart of publication period
2022
2020
2014
2010
2009

Co-Authors (by relevance)

  • Hodson, Nigel
  • Ligorio, Cosimo
  • Bella, Jordi
  • Hoyland, Judith A.
  • Vitale, Mattia
  • Mcavan, Bethan
  • Allan, Chris
  • Oreilly, Rachel K.
  • Li, Zehua
  • Binch, Abbie L. A.
  • Arno, Maria C.
  • Platt, Christopher I.
  • Inam, Maria
  • Weems, Andrew C.
  • Dove, Andrew P.
  • Mcconnell, James C.
  • Clarke, Louise E.
  • Sherratt, Michael J.
  • Derby, Brian
  • Liu, Ruixue
  • Fraylich, Michael R.
  • Saunders, Brian R.
  • Shakesheff, Kevin
  • Baird, Pauline
  • Alexander, Cameron
  • Freemont, Tony J.
  • Cellesi, Francesco
  • Freemont, Anthony J.
  • Hoyland, Judith
  • Gough, Julie
  • Ulijn, Rein V.
  • Hirst, Andrew R.
  • Saiani, Alberto
  • Jayawarna, Vineetha
OrganizationsLocationPeople

article

Thermally-triggered gelation of PLGA dispersions: Towards an injectable colloidal cell delivery system

  • Liu, Ruixue
  • Richardson, Stephen M.
  • Fraylich, Michael R.
  • Hoyland, Judith A.
  • Saunders, Brian R.
  • Shakesheff, Kevin
  • Baird, Pauline
  • Alexander, Cameron
  • Freemont, Tony J.
  • Cellesi, Francesco
Abstract

In this study the properties of poly(d,l-lactide-co-glycolide) (PLGA) dispersions containing a thermoresponsive cationic copolymer were investigated. The PLGA dispersions were prepared by interfacial deposition in aqueous solution and were rendered thermoresponsive by addition of a cationic poly(N-isopropyl acrylamide) (PNIPAm) graft copolymer. The copolymers used had the general composition PDMAx+-g-(PNIPAmn)y. DMA+ is quarternarized N,N-dimethylaminoethyl methacrylate. The PDMAx+-g-(PNIPAmn)y copolymers have x and y values that originate from the macroinitiator used for their preparation; values for n correspond to the PNIPAm arm length. The thermoresponsive dispersions were characterised using photon correlation spectroscopy, turbidity measurements and electrophoretic mobility measurements. A strong electrostatic attraction between the anionic PLGA particles and cationic copolymer was present and the dispersions showed thermally-triggered gelation at total polymer volume fractions as low as 0.015. These new PLGA gels, which formed at about 32 °C, had elastic modulus values that could be controlled using dispersion composition. Scanning electron micrographs of the gels showed high porosity and interconnectivity of elongated pores. Remarkably, the gels were flexible and had critical yield strains as high as 160%. The ability of the gels to support growth of bovine nucleus pulposus cells was investigated using two-dimensional cell culture. The cells proliferated and remained viable on the gels after 3 days. The results suggest that this general family of biodegradable thermogelling PLGA dispersions, introduced here for the first time, may have longer-term application as an injectable colloidal cell delivery system. © 2009 Elsevier Inc. All rights reserved.

Topics
  • Deposition
  • impedance spectroscopy
  • pore
  • dispersion
  • mobility
  • two-dimensional
  • porosity
  • interfacial
  • copolymer
  • gelation