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| Naji, M. |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Petrov, R. H. | Madrid |
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| Kočí, Jan | Prague |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ali, M. A. |
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| Azevedo, Nuno Monteiro |
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Waigh, Thomas A.
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Publications (6/6 displayed)
- 2014Reassessment of the importance of mucins in determining sputum properties in cystic fibrosiscitations
- 2014Particle tracking microrheology of purified gastrointestinal mucinscitations
- 2008Thermal fluctuations of fibrin fibres at short time scalescitations
- 2008Double-globular structure of porcine stomach mucin: A small-angle X-ray scattering studycitations
- 2008Modulated optical phase conjugation in rhodamine 110 doped boric acid glass saturable absorber thin filmscitations
- 2008Optical coherence tomography picorheology of biopolymer solutionscitations
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article
Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis
Abstract
Background: There is conflicting evidence about the importance of airway mucins (MUC5AC and MUC5B) in determining physical properties of sputum in cystic fibrosis (CF). We studied the effects of endogenous degradation of mucins on CF sputum elasticity and apparent mucin concentrations. Methods: Elastic shear moduli (G') and mucin concentrations in sputum of 12 CF patients were measured before and after incubation at 37. °C for 60. min. Results: G' fell from a median of 5.98 to 4.70. Pa (p. = 0.01). There were significant falls in MUC5AC (8.2 to 5.2. μg/ml, p. = 0.02) and MUC5B (17.3 to 12.5. μg/ml, p. = 0.02) over the same period, and associated decrease in molecular weight and size. Conclusions: Sputum is not inert and degradation reduces apparent mucin concentrations and sputum elasticity. Even if care is taken to process samples rapidly, sputum may therefore differ from secretions retained in airways. Previous studies may have underestimated the role of mucins in CF sputum. © 2013 European Cystic Fibrosis Society.