Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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Naji, M.
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Sack, I.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (23/23 displayed)

  • 2024On the relationship between viscoelasticity and water diffusion in soft biological tissues.3citations
  • 2022Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties.18citations
  • 2021Real-Time Multifrequency MR Elastography of the Human Brain Reveals Rapid Changes in Viscoelasticity in Response to the Valsalva Maneuver.19citations
  • 2020Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: Effect of cerebral arterial pulsation on brain viscoelasticity.25citations
  • 2019Sensitivity of multifrequency magnetic resonance elastography and diffusion-weighted imaging to cellular and stromal integrity of liver tissue.12citations
  • 2018Combining viscoelasticity, diffusivity and volume of the hippocampus for the diagnosis of Alzheimer's disease based on magnetic resonance imaging.86citations
  • 2015Tabletop magnetic resonance elastography for the measurement of viscoelastic parameters of small tissue samples.27citations
  • 2014High-resolution mechanical imaging of the kidney.27citations
  • 2014Wideband MRE and static mechanical indentation of human liver specimen: sensitivity of viscoelastic constants to the alteration of tissue structure in hepatic fibrosis.42citations
  • 2014In vivo time-harmonic multifrequency elastography of the human liver.39citations
  • 2013Compression-sensitive magnetic resonance elastography.18citations
  • 2013Isovolumetric elasticity alteration in the human heart detected by in vivo time-harmonic elastography.18citations
  • 2012Fractal network dimension and viscoelastic powerlaw behavior: I. A modeling approach based on a coarse-graining procedure combined with shear oscillatory rheometry.58citations
  • 2010Viscoelasticity-based MR elastography of skeletal muscle.95citations
  • 2010Viscoelasticity-based staging of hepatic fibrosis with multifrequency MR elastography.207citations
  • 2010Viscoelastic properties of liver measured by oscillatory rheometry and multifrequency magnetic resonance elastography.93citations
  • 2008Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography.280citations
  • 2008Assessment of liver viscoelasticity using multifrequency MR elastography.231citations
  • 2007Three-dimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain.84citations
  • 2007Noninvasive assessment of the rheological behavior of human organs using multifrequency MR elastography: a study of brain and liver viscoelasticity.295citations
  • 2006Shear wave group velocity inversion in MR elastography of human skeletal muscle.117citations
  • 2003Electromagnetic actuator for generating variably oriented shear waves in MR elastography.36citations
  • 2002Analysis of wave patterns in MR elastography of skeletal muscle using coupled harmonic oscillator simulations.citations

Places of action

Chart of shared publication
Safraou, Y.
1 / 1 shared
Pagel, K.
1 / 6 shared
Rg, Wells
1 / 1 shared
Braun, J.
6 / 35 shared
Pa, Dantas De Moraes
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Zappe, A.
1 / 1 shared
Tzschätzsch, H.
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Im, Sauer
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Kh, Hillebrandt
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Meyer, Tom
1 / 1 shared
Guo, J.
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Bernarding, J.
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Snellings, J.
1 / 1 shared
Budday, S.
1 / 5 shared
Herthum, H.
2 / 2 shared
Shahryari, M.
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Bertalan, G.
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Morr, A.
1 / 1 shared
Franze, K.
1 / 1 shared
Rd, Greenhalgh
1 / 1 shared
Schröder, L.
1 / 1 shared
Alzheimer, C.
1 / 1 shared
Becker, J.
1 / 9 shared
Braun, Jürgen
17 / 26 shared
Schrank, F.
3 / 4 shared
Görner, S.
1 / 1 shared
Warmuth, Carsten
2 / 2 shared
Hetzer, S.
1 / 1 shared
Neubauer, H.
1 / 1 shared
Pfeuffer, J.
1 / 1 shared
Hirsch, S.
5 / 6 shared
Kreft, B.
1 / 1 shared
Elgeti, T.
1 / 1 shared
Aa, De Schellenberger
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Polchlopek, B.
1 / 1 shared
Garczynska, K.
1 / 1 shared
Pa, Janmey
1 / 1 shared
Lm, Gerischer
1 / 1 shared
Köbe, T.
1 / 1 shared
Fehlner, A.
1 / 1 shared
Antonenko, D.
1 / 1 shared
Grittner, U.
1 / 2 shared
Flöel, A.
1 / 2 shared
Prehn, K.
1 / 2 shared
Ipek-Ugay, S.
2 / 2 shared
Ledwig, M.
1 / 1 shared
Drießle, T.
1 / 1 shared
Kj, Streitberger
2 / 2 shared
Fischer, T.
2 / 16 shared
Somasundaram, Rajan
3 / 3 shared
Seehofer, D.
1 / 1 shared
Kamphues, C.
1 / 1 shared
Jöhrens, K.
1 / 1 shared
Freise, C.
1 / 1 shared
Asbach, P.
4 / 4 shared
Reiter, R.
1 / 2 shared
Stockmann, M.
1 / 3 shared
Samani, A.
1 / 1 shared
Schultz, M.
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Gentz, E.
1 / 1 shared
Klaua, R.
2 / 2 shared
Tzschaetzsch, H.
1 / 1 shared
Beyer, F.
1 / 4 shared
Papazoglou, S.
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Hättasch, R.
1 / 1 shared
Knebel, F.
1 / 1 shared
Kv, Jenderka
1 / 1 shared
Posnansky, O.
1 / 1 shared
Klatt, D.
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Loddenkemper, C.
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Hamm, B.
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Muche, M.
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Rieger, A.
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Schlosser, B.
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Biermer, M.
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Berg, T.
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Korth, Y.
1 / 1 shared
Vogt, R.
1 / 1 shared
Friedrich, C.
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Beierbach, B.
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Hamhaber, U.
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Rump, J.
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Braun, K.
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Co-Authors (by relevance)

  • Safraou, Y.
  • Pagel, K.
  • Rg, Wells
  • Braun, J.
  • Pa, Dantas De Moraes
  • Zappe, A.
  • Tzschätzsch, H.
  • Im, Sauer
  • Kh, Hillebrandt
  • Meyer, Tom
  • Guo, J.
  • Bernarding, J.
  • Snellings, J.
  • Budday, S.
  • Herthum, H.
  • Shahryari, M.
  • Bertalan, G.
  • Morr, A.
  • Franze, K.
  • Rd, Greenhalgh
  • Schröder, L.
  • Alzheimer, C.
  • Becker, J.
  • Braun, Jürgen
  • Schrank, F.
  • Görner, S.
  • Warmuth, Carsten
  • Hetzer, S.
  • Neubauer, H.
  • Pfeuffer, J.
  • Hirsch, S.
  • Kreft, B.
  • Elgeti, T.
  • Aa, De Schellenberger
  • Polchlopek, B.
  • Garczynska, K.
  • Pa, Janmey
  • Lm, Gerischer
  • Köbe, T.
  • Fehlner, A.
  • Antonenko, D.
  • Grittner, U.
  • Flöel, A.
  • Prehn, K.
  • Ipek-Ugay, S.
  • Ledwig, M.
  • Drießle, T.
  • Kj, Streitberger
  • Fischer, T.
  • Somasundaram, Rajan
  • Seehofer, D.
  • Kamphues, C.
  • Jöhrens, K.
  • Freise, C.
  • Asbach, P.
  • Reiter, R.
  • Stockmann, M.
  • Samani, A.
  • Schultz, M.
  • Gentz, E.
  • Klaua, R.
  • Tzschaetzsch, H.
  • Beyer, F.
  • Papazoglou, S.
  • Hättasch, R.
  • Knebel, F.
  • Kv, Jenderka
  • Posnansky, O.
  • Klatt, D.
  • Loddenkemper, C.
  • Hamm, B.
  • Muche, M.
  • Rieger, A.
  • Schlosser, B.
  • Biermer, M.
  • Berg, T.
  • Korth, Y.
  • Vogt, R.
  • Friedrich, C.
  • Beierbach, B.
  • Hamhaber, U.
  • Rump, J.
  • Braun, K.
OrganizationsLocationPeople

article

Wideband MRE and static mechanical indentation of human liver specimen: sensitivity of viscoelastic constants to the alteration of tissue structure in hepatic fibrosis.

  • Somasundaram, Rajan
  • Seehofer, D.
  • Kamphues, C.
  • Braun, J.
  • Jöhrens, K.
  • Freise, C.
  • Sack, I.
  • Asbach, P.
  • Reiter, R.
  • Stockmann, M.
  • Samani, A.
Abstract

Despite the success of elastography in grading hepatic fibrosis by stiffness related noninvasive markers the relationship between viscoelastic constants in the liver and tissue structure remains unclear. We therefore studied the mechanical properties of 16 human liver specimens with different degrees of fibrosis, inflammation and steatosis by wideband magnetic resonance elastography (MRE) and static indentation experiments providing the specimens׳ static Young׳s modulus (E), dynamic storage modulus (G') and dynamic loss modulus (G″). A frequency-independent shear modulus μ and a powerlaw exponent α were obtained by fitting G' and G″ using the two-parameter sprinpot model. The mechanical parameters were compared to the specimens׳ histology derived parameters such as degree of Fibrosis (F), inflammation score and fat score, amount of hydroxyproline (HYP) used for quantification of collagen, blood markers and presurgery in vivo function tests. The frequency averaged parameters G', G″ and μ were significantly correlated with F (G': R=0.762, G″: R=0.830; μ: R=0.744; all P<0.01) and HYP (G': R=0.712; G″: R=0.720; μ: R=0.731; all P<0.01). The powerlaw exponent α displayed an inverse correlation with F (R=-0.590, P=0.034) and a trend of inverse correlation with HYP (R=-0.470, P=0.089). The static Young׳s modulus E was less correlated with F (R=0.587, P=0.022) and not sensitive to HYP. Although inflammation was highly correlated with F (R=0.773, P<0.001), no interaction was discernable between inflammation and mechanical parameters measured in this study. Other histological and blood markers as well as liver function test were correlated with neither F nor the measured mechanical parameters. In conclusion, viscoelastic constants measured by wideband MRE are highly sensitive to histologically proven fibrosis. Our results suggest that, in addition to the amount of connective tissue, subtle structural changes of the viscoelastic matrix determine the sensitivity of mechanical tissue properties to hepatic fibrosis.

Topics
  • experiment
  • laser emission spectroscopy