| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bouten, Cvc Carlijn
Eindhoven University of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2023How Smart are Smart Materials?citations
- 2020Optimization of Anti-kinking Designs for Vascular Grafts Based on Supramolecular Materialscitations
- 2020Imaging the In Vivo Degradation of Tissue Engineering Implants by Use of Supramolecular Radiopaque Biomaterialscitations
- 2019Macrophage-driven biomaterial degradation depends on scaffold microarchitecturecitations
- 2018Intrinsic cell stress is independent of organization in engineered cell sheetscitations
- 2017Biomaterial-driven in situ cardiovascular tissue engineering : a multi-disciplinary perspectivecitations
- 2017Porous scaffolds using dual electrospinning for in situ cardiovascular tissue engineeringcitations
- 2017Mechanically robust electrospun hydrogel scaffolds crosslinked via supramolecular interactionscitations
- 2015Hydrolytic and oxidative degradation of electrospun supramolecular biomaterialscitations
- 2015Hydrolytic and oxidative degradation of electrospun supramolecular biomaterials:In vitro degradation pathwayscitations
- 2014Monocytic cells become less compressible but more deformable upon activationcitations
- 2013Mechanical analysis of ovine and pediatric pulmonary artery for heart valve stent designcitations
- 2003Finite element model of mechanically induced collagen fiber synthesis and degradation in the aortic valvecitations
Places of action
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article
Mechanical analysis of ovine and pediatric pulmonary artery for heart valve stent design
Abstract
Transcatheter heart valve replacement is an attractive and promising technique for congenital as well as acquired heart valve disease. In this procedure, the replacement valve is mounted in a stent that is expanded at the aimed valve position and fixated by clamping. However, for this technique to be appropriate for pediatric patients, the material properties of the host tissue need to be determined to design stents that can be optimized for this particular application. In this study we performed equibiaxial tensile tests on four adult ovine pulmonary artery walls and compared the outcomes with one pediatric pulmonary artery. Results show that the pediatric pulmonary artery was significantly thinner (1.06±0.36. mm (mean±SD)) than ovine tissue (2.85±0.40. mm), considerably stiffer for strain values that exceed the physiological conditions (beyond 50% strain in the circumferential and 60% in the longitudinal direction), more anisotropic (with a significant difference in stiffness between the longitudinal and circumferential directions beyond 60% strain) and presented stronger non-linear stress-strain behavior at equivalent strains (beyond 26% strain) compared to ovine tissue. These discrepancies suggest that stents validated and optimized using the ovine pre-clinical model might not perform satisfactorily in pediatric patients. The material parameters derived from this study may be used to develop stent designs for both applications using computational models. © 2013 Elsevier Ltd.