| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Buschmann, Johanna
University of Zurich
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Pro-angiogenic and antibacterial copper containing nanoparticles in PLGA/amorphous calcium phosphate bone nanocompositescitations
- 2019Modification of silicone elastomers with Bioglass 45S5® increases in ovo tissue biointegrationcitations
- 20193D microtissue-derived human stem cells seeded on electrospun nanocomposites under shear stress: Modulation of gene expression.citations
- 2019Hybrid nanocomposite as a chest wall graft with improved integration by adipose-derived stem cells.citations
- 2018Cyclic uniaxial compression of human stem cells seeded on a bone biomimetic nanocomposite decreases anti-osteogenic commitment evoked by shear stress.citations
- 2017Effects of seeding adipose-derived stem cells on electrospun nanocomposite used as chest wall graft in a murine model.citations
- 2017Modulation of gene expression in human adipose-derived stem cells seeded on PLGA or biomimetic nanocomposite: comparison of 2D films and 3D electrospun meshes – the “real” comparison
- 2016Adipose-derived stem cell seeded biominerizable nanocomposite for chest wall repair: Suppression of inflammatory cellular response in a murine model
- 2015Tissue mechanics of piled critical size biomimetic and biominerizable nanocomposites: Formation of bioreactor-induced stem cell gradients under perfusion and compression.citations
- 2014Proliferation of ASC-derived endothelial cells in a 3D electrospun mesh: Impact of bone-biomimetic nanocomposite and co-culture with ASC-derived osteoblasts
- 2014Proliferation of ASC-derived endothelial cells in a 3D electrospun mesh: impact of bone-biomimetic nanocomposite and co-culture with ASC-derived osteoblasts.citations
- 2013Bioactive nanocomposite for chest-wall replacement: Cellular response in a murine model.citations
- 2013Tissue Engineered Bone Grafts Based on Biomimetic Nanocomposite PLGA/a-CaP Scaffold and Human Adipose-Derived Stem Cells
- 2012Tissue Engineered Bone Grafts Based on Biomeimetic Nanocomposite PLGA/Amorphous Calcium Phosphate Scaffold and human Adipose-derived Stem Cells
- 2012Tissue engineered bone grafts based on biomimetic nanocomposite PLGA/amorphous calcium phosphate scaffold and human adipose-derived stem cells.citations
Places of action
| Organizations | Location | People |
|---|
article
Tissue engineered bone grafts based on biomimetic nanocomposite PLGA/amorphous calcium phosphate scaffold and human adipose-derived stem cells.
Abstract
For tissue engineering of critical size bone grafts, nanocomposites are getting more and more attractive due to their controllable physical and biological properties. We report in vitro and in vivo behaviour of an electrospun nanocomposite based on poly-lactic-co-glycolic acid and amorphous calcium phosphate nanoparticles (PLGA/a-CaP) seeded with human adipose-derived stem cells (ASC) compared to PLGA. Major findings were that cell attachment, three-dimensional ingrowth and proliferation were very good on both materials. Cell morphology changed from a spindle-shaped fibroblast-like form to a more roundish type when ASC were seeded on PLGA, while they retained their morphology on PLGA/a-CaP. Moreover, we found ASC differentiation to a phenotype committed towards osteogenesis when a-CaP nanoparticles were suspended in normal culture medium without any osteogenic supplements, which renders a-CaP nanoparticles an interesting osteoinductive component for the synthesis of other nanocomposites than PLGA/a-CaP. Finally, electrospun PLGA/a-CaP scaffold architecture is suitable for a rapid and homogenous vascularisation confirmed by a complete penetration by avian vessels from the chick chorioallantoic membrane (CAM) within one week.