| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Tho, Ingunn
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2023Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tablets ; ENEngelskEnglishImpact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tabletscitations
- 2023Co-administration of Intravenous Drugscitations
- 2023Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tabletscitations
- 2022A new method to determine drug-polymer solubility through enthalpy of melting and mixing ; ENEngelskEnglishA new method to determine drug-polymer solubility through enthalpy of melting and mixingcitations
- 2022A new method to determine drug-polymer solubility through enthalpy of melting and mixingcitations
- 2021Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersioncitations
- 2020Functionalised calcium carbonate as a coformer to stabilize amorphous drugs by mechanochemical activationcitations
- 2019Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffoldcitations
- 2015Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapycitations
- 2015Chitosan in Mucoadhesive Drug Delivery : Focus on Local Vaginal Therapycitations
Places of action
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article
A new method to determine drug-polymer solubility through enthalpy of melting and mixing
Abstract
<p>In this study, a new method to determine the solubility of crystalline drugs in (amorphous) polymers is proposed. The method utilizes annealing of supersaturated amorphous solid dispersions to achieve equilibrium between dissolved and recrystallized drug. By measuring the enthalpy of melting and mixing (H<sub>m+mix</sub>) of the recrystallized drug, the equilibrium solubility of the drug in the polymer at the annealing temperature is determined. The equilibrium solubilities at these elevated temperatures were used to extrapolate to room temperature using the Flory-Huggins model. The new H<sub>m+mix</sub> method showed solubility predictions in line with the melting point depression (MPD) and recrystallization (RC) methods for indomethacin (IMC) -polyvinylpyrrolidone (PVP). For IMC-hydroxypropyl methylcellulose (HPMC), the MPD method plateaued rapidly, leaving only one usable data point. The RC method showed large variations in the solubility predictions possibly due to a narrow glass transition temperature (T<sub>g</sub>) window or inaccurate T<sub>g</sub> determination. In contrast, the new H<sub>m+mix</sub> method showed robust solubility prediction over the entire annealing temperature range with low variation and narrow error margins after extrapolation for both drug-polymer systems. The new H<sub>m+mix</sub> method was able to accurately determine the drug-polymer solubility of IMC-HPMC, showing promise as a new tool to determine the solubility of problematic drug-polymer systems.</p>