| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Školáková, Andrea
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2024Exploring the microstructure, mechanical properties, and corrosion resistance of innovative bioabsorbable Zn-Mg-(Si) alloys fabricated via powder metallurgy techniquescitations
- 2024Exploring the microstructure, mechanical properties, and corrosion resistance of innovative bioabsorbable Zn-Mg-(Si) alloys fabricated via powder metallurgy techniquescitations
- 2024Advantages of rapid solidification over casting of Mg-0.4Zn-1Y alloycitations
- 2023Effect of Double-Step and Strain-Assisted Tempering on Properties of Medium-Carbon Steelcitations
- 2023A detailed mechanism of degradation behaviour of biodegradable as-ECAPed Zn-0.8Mg-0.2Sr with emphasis on localized corrosion attackcitations
- 2023Suppression of mechanical instability in bioabsorbable ultrafine-grained Zn through in-situ stabilization by ZnO nanodispersoidscitations
- 2022Investigation of tadalafil molecular arrangement in solid dispersions using inverse gas chromatography and Raman mappingcitations
- 2021Microstructure evolution and mechanical performance of ternary Zn-0.8Mg-0.2Sr (wt. %) alloy processed by equal-channel angular pressingcitations
- 2021Influence of Ceramic Particles Character on Resulted Properties of Zinc-Hydroxyapatite/Monetite Compositescitations
Places of action
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article
Investigation of tadalafil molecular arrangement in solid dispersions using inverse gas chromatography and Raman mapping
Abstract
The aim of this study was to investigate the molecular structures of tadalafil solid dispersions prepared by different techniques and further to relate them to surface free energy information indicating the final amor-phousness of the product. Thus, we tried to complement the existing knowledge of solid dispersion formation. Poorly water-soluble tadalafil was combined with different polymers, i.e. Kollidon (R) 12 PF, Kollidon (R) VA 64 and Soluplus (R), to form model systems. To assess the extent of drug-polymer miscibility, we studied model solid dispersion surface energy using inverse gas chromatography and phase micro-structure using confocal Raman microscopy. The selection of the preparation method was found to play a crucial role in the molecular arrangement of the incorporated drug and the polymer in resulting solid dispersion. Our results showed that a lower surface free energy indicated the formation of a more homogeneous solid dispersion. Conversely, a higher surface free energy corresponded to the heterogeneous systems containing tadalafil amorphous clusters that were captured by Raman mapping. Thus, we successfully introduced a novel evaluation approach of the drug mo-lecular arrangement in solid dispersions that is especially useful for examining the miscibility of the components when the conventional characterizing techniques are inconclusive or yield variable results.