Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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Materials Map under construction

The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (1/1 displayed)

  • 2021Effect of co-milling on dissolution rate of poorly soluble drugs20citations

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Chart of shared publication
Kuentz, Martin
1 / 5 shared
Lojková, Michaela
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Prausová, Kateřina
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Brokesova, Jana
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Patera, Jan
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Zámostný, Petr
1 / 3 shared
Chart of publication period
2021

Co-Authors (by relevance)

  • Kuentz, Martin
  • Lojková, Michaela
  • Prausová, Kateřina
  • Brokesova, Jana
  • Patera, Jan
  • Zámostný, Petr
OrganizationsLocationPeople

article

Effect of co-milling on dissolution rate of poorly soluble drugs

  • Kuentz, Martin
  • Lojková, Michaela
  • Prausová, Kateřina
  • Epikaridisová, Julie
  • Brokesova, Jana
  • Patera, Jan
  • Zámostný, Petr
Abstract

Co-milling of a drug with a co-former is an efficient technique to improve the solubility of drugs. Besides the particle size reduction, the co-milling process induces a structural disorder and the creation of amorphous regions. The extent of drug solubility enhancement is dependent on the proper choice of co-milling co-former. The aim of this work was to compare the effects of different co-formers (meglumine and polyvinylpyrrolidone) on the dissolution rates of glass forming (indomethacin) and non-glass forming (mefenamic acid) model drugs. A positive impact of the co-milling on the dissolution behavior was observed in all co-milled mixtures, even if no substantial amorphization was observed. While meglumine exhibited pronounced effects on the dissolution rate of both drugs, the slightest enhancement was observed in mixtures with polyvinylpyrrolidone. The evaluation of specific release rate revealed the surface activation of drug particle is responsible for improving the dissolution rate of both drug types, but for the glass former, this surface activation could be persistent while maintaining a high dissolution rate even until a high fraction of drug is released. Our results, therefore, indicate that adequate co-former choice and consideration of drug glass forming ability are important for a successful co-milling approach to poorly water-soluble drugs.

Topics
  • impedance spectroscopy
  • surface
  • amorphous
  • grinding
  • glass
  • glass
  • milling
  • activation