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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Nielsen, Ulla Gro
University of Southern Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2023The effects of low oxidation-reduction potential on the performance of full-scale hybrid membrane-aerated biofilm reactorscitations
- 2021Synthesis and Thermal Degradation of MAl4(OH)12SO4·3H2O with M = Co2+, Ni2+, Cu2+, and Zn2+citations
- 2021Synthesis and Thermal Degradation of MAl 4 (OH) 12 SO 4 ·3H 2 O with M = Co 2+ , Ni 2+ , Cu 2+ , and Zn 2+citations
- 2020The Effect of oxygen defects on the structural evolution of LiVPO4F1−yoy cathode materialscitations
- 2020Remarkable reversal of 13 C-NMR assignment in d 1 , d 2 compared to d 8 , d 9 acetylacetonate complexes:Analysis and explanation based on solid-state MAS NMR and computationscitations
- 2020Remarkable reversal of 13C-NMR assignment in d1, d2 compared to d8, d9 acetylacetonate complexescitations
- 2019Reactivity of magnesium borohydride – Metal hydride composites, γ-Mg(BH4)2-MHx, M = Li, Na, Mg, Cacitations
- 2019Reactivity of magnesium borohydride – Metal hydride composites, $mathrm{γ-Mg(BH_{4})_{2}-MH_{x}, M = Li, Na, Mg, Ca}$citations
- 2019Montmorillonite-surfactant hybrid particles for modulating intestinal P-glycoprotein-mediated transportcitations
- 2019Reactivity of magnesium borohydride – Metal hydride composites, γ-Mg(BH 4 ) 2 -MH x , M = Li, Na, Mg, Cacitations
- 2019Synthesis and Structural Characterization of a Pure ZnAl 4 (OH) 12 (SO 4 )·2.6H 2 O Layered Double Hydroxidecitations
- 2019Synthesis and Structural Characterization of a Pure ZnAl 4 (OH) 12 (SO 4 )·2.6H 2 O Layered Double Hydroxidecitations
- 2018Order in disorder:solution and solid-state studies of [MM] wheels (M = Cr, Al; M = Ni, Zn)citations
- 2018Order in disordercitations
- 2018In situ processing of fluorinated carbon—Lithium fluoride nanocompositescitations
- 2016The role of aluminium as an additive element in the synthesis of porous 4H-silicon carbidecitations
- 2016The role of aluminium as an additive element in the synthesis of porous 4H-silicon carbidecitations
- 2015How the Method of Synthesis Governs the Local and Global Structure of Zinc Aluminum Layered Double Hydroxidescitations
- 2015How the Method of Synthesis Governs the Local and Global Structure of Zinc Aluminum Layered Double Hydroxidescitations
- 2015The effect of preparation method on the proton conductivity of indium doped tin pyrophosphatescitations
- 2014The stoichiometry of synthetic alunite as a function of hydrothermal ageing investigated by solid-state NMR spectroscopy, powder X-ray diffraction, and infrared spectroscopycitations
- 2012Preparation of Nafion 117™-SnO 2 Composite Membranes using an Ion-Exchange Methodcitations
- 2012Preparation of Nafion 117™-SnO2 Composite Membranes using an Ion-Exchange Methodcitations
- 2010Preparation of Nafion 117™-SnO2 Composite Membranes using an Ion-Exchange Method
- 2010Fremstilling af Nafion 117™-SnO 2 kompositmembraner ved brug af en ionbytningsmetode ; Preparation of Nafion 117™-SnO 2 Composite Membranes using an Ion-Exchange Method
Places of action
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article
Montmorillonite-surfactant hybrid particles for modulating intestinal P-glycoprotein-mediated transport
Abstract
In the small intestine, P-glycoprotein (P-gp) may limit the permeability of its substrates, which lead to reduced oral absorption. To circumvent the effect of P-gp, a nanocomposite material termed montmorillonite-surfactant hybrid particles was developed. The particles consisted of montmorillonite, the P-gp-inhibiting, nonionic surfactant, polysorbate 20, and the P-gp substrate, digoxin. The present study aimed to investigate if montmorillonite-surfactant hybrid particles could modulate the absorption of digoxin in vivo. Montmorillonite-surfactant hybrid particles were prepared by lyophilising an aqueous suspension of the constituents. Scanning electron microscopy, thermogravimetric analysis, and powder X-ray diffraction revealed an altered surface morphology, decreased water content, and intercalation of polysorbate 20 between montmorillonite layers. The particles were administered orally to Sprague Dawley rats, and digoxin was quantified by liquid chromatography-tandem mass spectrometry. Control digoxin-containing montmorillonite decreased the exposure of digoxin. In contrast, montmorillonite-surfactant hybrid particles increased AUC and C max by 31 and 91%, respectively, compared to digoxin in solution. It was hypothesised that montmorillonite-surfactant hybrid particles increased digoxin exposure by forming mucosa-localised elevated concentrations of polysorbate 20 and digoxin, which enhanced the inhibitory effect of polysorbate 20 on P-gp.