Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (5/5 displayed)

  • 2021Custom silicone elastomers for improved mechanical performance and reduced hormone binding in a dapivirine/levonorgestrel vaginal ringcitations
  • 2021Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel17citations
  • 2019Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers28citations
  • 2019In vitro release testing methods for drug-releasing vaginal rings30citations
  • 2017Packing polymorphism of dapivirine and its impact on the performance of a dapivirine-releasing silicone elastomer vaginal ring20citations

Places of action

Chart of shared publication
Murphy, Diarmaid
5 / 10 shared
Boyd, Peter
5 / 16 shared
Martin, Francois
2 / 3 shared
Hansraj, Bashir
2 / 3 shared
Brown, Leanne
1 / 1 shared
Devlin, Brid
4 / 10 shared
Kihara, Matthew
2 / 2 shared
Dangi, Bindi
2 / 2 shared
Mcmullen, Nicole
2 / 2 shared
Kleinbeck, Kyle
3 / 3 shared
Malcolm, Karl
5 / 21 shared
Mccoy, Clare
5 / 12 shared
Brown, Leeanne
1 / 1 shared
Variano, Bruce
1 / 2 shared
Derrick, Tiffany
1 / 1 shared
Chart of publication period
2021
2019
2017

Co-Authors (by relevance)

  • Murphy, Diarmaid
  • Boyd, Peter
  • Martin, Francois
  • Hansraj, Bashir
  • Brown, Leanne
  • Devlin, Brid
  • Kihara, Matthew
  • Dangi, Bindi
  • Mcmullen, Nicole
  • Kleinbeck, Kyle
  • Malcolm, Karl
  • Mccoy, Clare
  • Brown, Leeanne
  • Variano, Bruce
  • Derrick, Tiffany
OrganizationsLocationPeople

article

Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers

  • Murphy, Diarmaid
  • Boyd, Peter
  • Kleinbeck, Kyle
  • Spence, Patrick
  • Malcolm, Karl
  • Devlin, Brid
  • Mccoy, Clare
Abstract

With a dapivirine-releasing vaginal ring having successfully completed late-stage clinical testing for HIV prevention and currently undergoing regulatory review, there is now growing interest in next-generation multipurpose prevention technologies that seek to combine antiretroviral and contraceptive drugs within a single product. Here, we focus on ongoing efforts to develop a silicone elastomer vaginal ring releasing both dapivirine and levonorgestrel. Specifically, we evaluate various strategies aimed at both better understanding and reducing the tendency of levonorgestrel to bind with the elastomer, including: (i) formulation and post-manufacturing strategies aimed at reducing the extent of levonorgestrel reaction with addition-cure silicone elastomers; (ii) evaluation of a simple silicone system to model the complex elastomer; (iii) use of model compounds representing the enone and ethinyl moieties of levonorgestrel to probe the mode of addition of levonorgestrel to addition-cure silicone elastomers; and (iv) solution and solid-state 13C-NMR analysis to probe the structural features of the levonorgestrel-silicone system. The results demonstrate that both the enone and ethinyl groups within levonorgestrel undergo hydrosilylation reaction with hydrosiloxane groups in the silicone elastomer leading to binding. The results also highlight potential strategies for further optimising the dapivirine+levonorgestrel silicone vaginal ring formulation to ensure that the levonorgestrel is available for release.

Topics
  • impedance spectroscopy
  • compound
  • Nuclear Magnetic Resonance spectroscopy
  • elastomer