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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Goyanes, Alvaro
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2023Electrophotographic 3D printing of pharmaceutical films
- 2022Prediction of Solid-State Form of SLS 3D Printed Medicines Using NIR and Raman Spectroscopy
- 2020Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetroncitations
- 20203D printingcitations
- 20203D printed opioid medicines with alcohol-resistant and abuse-deterrent propertiescitations
- 2019Direct powder extrusion 3D printing: Fabrication of drug products using a novel single-step process.citations
- 2019Track-and-trace: Novel anti-counterfeit measures for 3D printed personalized drug products using smart material inks.citations
- 20193D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technologycitations
- 20183D printing of drug-loaded gyroid lattices using selective laser sinteringcitations
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article
Direct powder extrusion 3D printing: Fabrication of drug products using a novel single-step process.
Abstract
Three-dimensional (3D) printing is revolutionising how we envision manufacturing in the pharmaceutical field. Here, we report for the first time the use of direct powder extrusion 3D printing: a novel single-step printing process for the production of printlets (3D printed tablets) directly from powdered materials. This new 3D printing technology was used to prepare amorphous solid dispersions of itraconazole using four different grades of hydroxypropylcellulose (HPC - UL, SSL, SL and L). All of the printlets showed good mechanical and physical characteristics and no drug degradation. The printlets showed sustained drug release characteristics, with drug concentrations higher than the solubility of the drug itself. The printlets prepared with the ultra-low molecular grade (HPC - UL) showed faster drug release compared with the other HPC grades, attributed to the fact that itraconazole was found in a higher percentage as an amorphous solid dispersion. This work demonstrates the potential of this innovate technology to overcome one of the major disadvantages of fused deposition modelling (FDM) 3D printing by avoiding the need for preparation of filaments by hot melt extrusion (HME). This novel single-step technology could revolutionise the preparation of amorphous solid dispersions as final formulations and it may be especially suited for preclinical studies, where the quantity of drugs is limited and without the need of using traditional HME.