| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Markl, Daniel
University of Strathclyde
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2022Polymer pellet fabrication for accurate THz-TDS measurementscitations
- 2022Analysis of THz scattering of compacted granular materials using THz-TDScitations
- 2021Terahertz pulsed imaging as a new method for investigating the liquid transport kinetics of α-alumina powder compactscitations
- 2021Development of 3D printed rapid tooling for micro-injection mouldingcitations
- 2020Development and Validation of an in-line API Quantification Method Using AQbD Principles Based on UV-Vis Spectroscopy to Monitor and Optimise Continuous Hot Melt Extrusion Processcitations
- 2019Hot-melt extrusion process impact on polymer choice of glyburide solid dispersionscitations
- 2018Pharmaceutical-grade oral films as substrates for printed medicinecitations
- 2017On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipientcitations
- 2017Optics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive indexcitations
- 2016Multi-methodological investigation of the variability of the microstructure of HPMC hard capsulescitations
- 2013Hot melt extrusion as a continuous pharmaceutical manufacturing processcitations
- 2013Supervisory control system for monitoring a pharmaceutical hot melt extrusion processcitations
Places of action
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article
Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions
Abstract
<p>The aim of this study was to evaluate the choice of polymer and polymer level on the performance of the microstructure and wettability of hot-melt extruded solid dispersion of Glyburide (Gly) as a model drug. The produced solid dispersion were characterised using scanning electron microscopy (SEM), image analysis using a focus variation instrument (FVI), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), X-ray microtomography (XµT), dynamic contact angle measurement and dissolution analysis using biorelevant dissolution media (FASSIF). SEM and focus variation analysis showed that the microstructure and surface morphology was significantly different between samples produced. This was confirmed by further analysis using XµT which showed that an increase in polymer content brought about a decrease in the porosity of the hot-melt extruded dispersions. DSC suggested complete amorphorisation of Gly whereas XRPD suggested incomplete amorphorisation. The static and dynamic contact angle measurement correlated with the dissolution studies using FASSIF media indicating that the initial liquid imbibition process as captured by the dynamic contact angle directly affects the dissolution performance.</p>