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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Pezzoli, Romina
Technological University of the Shannon: Midlands Midwest
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2023Designing Sustainable Polymer Blendscitations
- 2023Designing sustainable polymer blends: tailoring mechanical properties and degradation behaviour in PHB/PLA/PCL blends in a seawater environmentcitations
- 2020Development of sustainable flexible packaging solutions using novel biodegradable and compostable polymer blends
- 2019Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble Indomethacin with Poly(vinyl pyrrolidone-co-vinyl acetate) and polyethylene oxide.citations
- 2019Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble indomethacin with poly(vinyl pyrrolidone-co-vinyl acetate)and polyethylene oxidecitations
- 2018Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate)citations
- 2018Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate).
Places of action
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article
Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate)
Abstract
<p>The investigation of the miscibility between active pharmaceutical ingredients (API's) and polymeric excipients is of great interest for the formulation and development of amorphous solid dispersions, especially in the context of the prediction of the stability of these systems. Two different methods were applied to determine the miscibility between model compounds poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA) and indomethacin (IND), viz. the measurement of the glass transition temperature (T<sub>g</sub>) and the melting point depression method framed on the Flory-Huggins theory. Measurement of the glass transition temperatures of the binary blends showed the formation of an amorphous single phase system between the PVPVA and the IND regardless of the composition. Variation of T<sub>g</sub> with the composition was well described by the Gordon-Taylor equation leading to the error of concluding lack of intermolecular interactions between the materials. Application of the Brostow-Chiu-Kalogeras-Vassilikou-Dova (BCKV) model shows a negative interaction parameter (a<sub>0</sub>) suggesting the presence of drug-drug intermolecular interactions. Application of the melting point depression method within the framework of the Flory-Huggins theory proved the miscibility of the system at temperatures close to the melting point of IND.</p>