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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Basit, Aw
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2023A case study on decentralized manufacturing of 3D printed medicines
- 2021Machine learning predicts 3D printing performance of over 900 drug delivery systems
- 2020Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron
- 2020M3DISEEN: A Novel Machine Learning Approach for Predicting the 3D Printability of Medicines
- 20203D printing: Principles and pharmaceutical applications of selective laser sintering
- 20193D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology.
- 2019An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems
- 2018Low temperature fused deposition modeling (FDM) 3D printing of thermolabile drugs.
- 20183D printing of drug-loaded gyroid lattices using selective laser sinteringcitations
- 2018Fabricating 3D printed orally disintegrating printlets using selective laser sintering
- 2017Selective laser sintering (SLS) 3D printing of medicines
- 2017Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing
- 20163D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems
- 2016Stereolithographic (SLA) 3D printing of oral modified-release dosage forms.
- 2015Effect of geometry on drug release from 3D printed tablets
- 2015Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing
- 2014Fused-filament 3D printing (3DP) for fabrication of tablets
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article
3D printing of drug-loaded gyroid lattices using selective laser sintering
Abstract
Three-dimensional printing (3DP) is gaining momentum in the field of pharmaceuticals, offering innovative opportunities for medicine manufacture. Selective laser sintering (SLS) is a novel, high resolution and single-step printing technology that we have recently introduced to the pharmaceutical sciences. The aim of this work was to use SLS 3DP to fabricate printlets (3D printed tablets) with cylindrical, gyroid lattice and bi-layer structures having customisable release characteristics. Paracetamol-loaded constructs from four different pharmaceutical grade polymers including polyethylene oxide, Eudragit (L100-55 and RL) and ethyl cellulose, were created using SLS 3DP. The novel gyroid lattice structure was able to modulate the drug release from all four polymers. This work is the first to demonstrate the feasibility of using SLS to achieve customised drug release properties of several polymers, in a swift, cost-effective manner, avoiding the need to alter the formulation composition. By creating these constructs, it is therefore possible to modify drug release, which in practice, could enable the tailoring of drug performance to the patient simply by changing the 3D design.