| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Markl, Daniel
University of Strathclyde
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2022Polymer pellet fabrication for accurate THz-TDS measurementscitations
- 2022Analysis of THz scattering of compacted granular materials using THz-TDScitations
- 2021Terahertz pulsed imaging as a new method for investigating the liquid transport kinetics of α-alumina powder compactscitations
- 2021Development of 3D printed rapid tooling for micro-injection mouldingcitations
- 2020Development and Validation of an in-line API Quantification Method Using AQbD Principles Based on UV-Vis Spectroscopy to Monitor and Optimise Continuous Hot Melt Extrusion Processcitations
- 2019Hot-melt extrusion process impact on polymer choice of glyburide solid dispersionscitations
- 2018Pharmaceutical-grade oral films as substrates for printed medicinecitations
- 2017On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipientcitations
- 2017Optics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive indexcitations
- 2016Multi-methodological investigation of the variability of the microstructure of HPMC hard capsulescitations
- 2013Hot melt extrusion as a continuous pharmaceutical manufacturing processcitations
- 2013Supervisory control system for monitoring a pharmaceutical hot melt extrusion processcitations
Places of action
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article
Pharmaceutical-grade oral films as substrates for printed medicine
Abstract
In contact-less printing, such as piezo-electric drop on demand printing used in the study, the drop formation process is independent of the substrate. This means that having developed a printable formulation, printed pharmaceutical dosage forms can be obtained on any pharmaceutical grade substrate, such as polymer-based films. In this work we evaluated eight different oral films based on their suitability as printing substrates for sodium picosulfate. The different polymer films were compared regarding printed spot morphology, chemical stability and dissolution profile. The morphology of printed sodium picosulfate was investigated with scanning electron microscopy and optical coherence tomography. The spreading of the deposited drops was found to be governed by the contact angle of the ink with the substrate. The form of the sodium picosulfate drops changed on microcrystalline cellulose films at ambient conditions over 8 weeks and stayed unchanged on other tested substrates. Sodium picosulfate remained amorphous on all substrates according to small and wide angle X-ray scattering, differential scanning calorimetry and polarized light microscopy measurements. The absence of chemical interactions between the drug and substrates, as indicated by infrared spectroscopy, makes all tested substrates suitable for printing sodium picosulfate onto them