Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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Publications (57/57 displayed)

  • 2023Dynamic Slip Casting: An Efficient Robotic Approach to Geometrically Variable Ceramic Part Productioncitations
  • 2023Nanocomposite hydrogels with polymer grafted silica nanoparticles, using glucose oxidase4citations
  • 2023Extra-wide deposition in extrusion additive manufacturing: A new convention for improved interlayer mechanical performance14citations
  • 2023Mechanical assessment of lower-limb prosthetic sockets after printing-path optimizationcitations
  • 2022AM lower-limb prosthetic socket: Using FEA for improved mechanical performance8citations
  • 2022Mechanoregulated trabecular bone adaptation: Progress report on in silico approaches6citations
  • 2022Double-network hydrogels reinforced with covalently bonded silica nanoparticles via 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide chemistry7citations
  • 2022MECHANICAL STIMULI IN PREDICTION OF TRABECULAR BONE ADAPTATION: NUMERICAL COMPARISONcitations
  • 2022Stability and mechanical performance of collagen films under different environmental conditions15citations
  • 2022Mechanical performance of 3D printed prosthetic sockets: An experimental and numerical study3citations
  • 2021Failure behaviour of human trabecular bone3citations
  • 2021Modification of energy band alignment and electric properties of Pt/Ba₀.₆Sr₀.₄TiO₃/Pt thin-film ferroelectric varactors by Ag impurities at interfacescitations
  • 2021Interfacial damage in flexible electronics with collagen substrate: Effect of environmental conditionscitations
  • 2021Structural integrity of 3D-printed prosthetic sockets: An experimental study for paediatric above-knee applications12citations
  • 2021The prismatic surface cell cooling coefficient: A novel cell design optimisation tool & thermal parameterization method for a 3D discretised electro-thermal equivalent-circuit modelcitations
  • 2020Nanoscale Mg-B via Surfactant Ball Milling of MgB 2 :Morphology, Composition, and Improved Hydrogen Storage Properties23citations
  • 2020The prismatic surface cell cooling coefficient: A novel cell design optimisation tool & thermal parameterization method for a 3D discretised electro-thermal equivalent-circuit model20citations
  • 2019Characterising variability and regional correlations of microstructure and mechanical competence of human tibial trabecular bone: An in-vivo HR-pQCT study27citations
  • 2019Open vessel free radical photopolymerization of double network gels for biomaterial applications using glucose oxidase8citations
  • 2019Fracture of three-dimensional lattices manufactured by selective laser melting38citations
  • 2019Osteogenic potential of sol-gel bioactive glasses containing manganese72citations
  • 2019Glass formation by severe plastic deformation of crystalline Cu|Zr nano-layers16citations
  • 2019Polydimethylsiloxane and poly(ether) ether ketone functionally graded composites for biomedical applications25citations
  • 2018Amorphous nickel nanophases inducing ferromagnetism in equiatomic Ni-Ti alloy15citations
  • 2018Numerical simulation of bone cutting: Hybrid SPH-FE approachcitations
  • 2018A Comparative Study between Hot-Melt Extrusion and Spray-Drying for the Manufacture of Anti-Hypertension Compatible Monolithic Fixed-Dose Combination Products38citations
  • 2018Numerical Simulation of Bone Cutting20citations
  • 2018Design and Beam Test Results for the sPHENIX Electromagnetic and Hadronic Calorimeter Prototypes19citations
  • 2018Fabrication of plasmonic TiN nanostructures by nitridation of nanoimprinted TiO2 nanoparticles30citations
  • 2017Stress-strain behavior of soils having undergone different amounts of internal erosion: (Paper and Abstract)citations
  • 2017Computational modelling of wounded tissue subject to negative pressure wound therapy following trans-femoral amputation7citations
  • 2017Evaluation of the chemical and biomechanical viscoelastic properties of decellularised tracheal scaffolds1citations
  • 2017Bidirectional Mapping between Architecture Model and Code for Synchronization8citations
  • 2017Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationshipscitations
  • 2016Computational modelling of mechanical behavior of biological tissues for biomedical applicationscitations
  • 2016Enhanced photovoltaic properties in bilayer BiFeO3/Bi-Mn-O thin films44citations
  • 2016Hollow Zeolite Single-Crystals Encapsulated Alloy Nanoparticles with Controlled Size and Composition42citations
  • 2015Fracture of cortical bone tissue3citations
  • 2015Effect of micromorphology of cortical bone tissue on crack propagation under dynamic loading4citations
  • 2015Epitaxial Bi2FeCrO6 Multiferroic Thin Film as a New Visible Light Absorbing Photocathode Material84citations
  • 2015Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes16citations
  • 2015Describing the deformation behaviour of TRIP and dual phase steels employing an irreversible thermodynamics formulation6citations
  • 2014Modelling fracture processes in bones8citations
  • 2014Size Control of Metal Nanoparticles Encapsulated in Zeolite Single Crystals and Application to Size-Selective Hydrogenationcitations
  • 2014Penetration of cutting tool into cortical bone: Experimental and numerical investigation of anisotropic mechanical behaviour44citations
  • 2013Analysis of fracture processes in cortical bone tissue89citations
  • 2013Metal Nanoparticle(s) in Single Crystal Hollow Zeolitecitations
  • 2013Fracture process in cortical bone: X-FEM analysis of microstructured models9citations
  • 2013Variability and anisotropy of mechanical behavior of cortical bone in tension and compression165citations
  • 2012Application of smooth-particle hydrodynamics in metal machining13citations
  • 2012Multi-phase microstructure design of a low-alloy TRIP-assisted steel through a combined computational and experimental methodology75citations
  • 2012Analysis of deformation characteristics of cortical bone tissue1citations
  • 2011Thermal and strain-induced chain ordering in lactic acid stereocopolymers: Influence of the composition in stereomers52citations
  • 2011Deformation and Fracture Behavior of Metallic Glassy Alloys and Glassy-Crystal Composites19citations
  • 2011Elastic and viscoelastic properties of glassy, quasicrystalline and crystalline phases in Zr65Cu5Ni10Al 7.5Pd12.5 alloys47citations
  • 2010Active chalcogenide glass photonics and electro-optics for the mid-infraredcitations
  • 2010Propagation of shear bands in metallic glasses and transition from serrated to non-serrated plastic flow at low temperatures42citations

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Co-Authors (by relevance)

  • Wu, R.
  • Moriuchi, S.
  • Stuart-Smith, R.
  • Anderson, Js
  • King, N.
  • Chen, Y.
  • Mohammed, Aa
  • Jones, Jr
  • Pinna, A.
  • Sang, T.
  • Mcadam, I.
  • Mitchell, N.
  • Allum, J.
  • Moetazedian, A.
  • Gleadall, A.
  • Silberschmidt, Vadim V.
  • Marinopoulos, T.
  • Smotrova, E.
  • Merrild, Ng
  • Mele, E.
  • Bose, S.
  • Williams, C. J.
  • Tashkinov, M.
  • Shalimov, A.
  • Klein, Andreas
  • Alff, Lambert
  • Komissinskiy, Philipp
  • Rachut, Karsten
  • Hirsch, S.
  • Flege, Stefan
  • Loveridge, M.
  • Shearing, P.
  • Yu, Y.
  • Patel, Y.
  • Tao, L.
  • Zhang, C.
  • Jnawali, A.
  • Modrow, N.
  • Marinescu, M.
  • Holloway, J.
  • Hales, A.
  • Heckel, C.
  • Hua, X.
  • Offer, G.
  • Sawvel, A. M.
  • Stavila, V.
  • Snider, J. L.
  • Liu, Y. S.
  • Eshelman, H. V.
  • Wood, B. C.
  • Gunda, H.
  • Klebanoff, L. E.
  • Ray, K. G.
  • Mattox, T. M.
  • Pham, A. L.
  • Heo, T. W.
  • York, W.
  • Jensen, T. R.
  • Cowgill, D. F.
  • Wijeratne, P.
  • Kang, S.
  • Jørgensen, M.
  • Walsh, J. S.
  • Du, J.
  • Brooke-Wavell, K.
  • Hartley, C.
  • Paggiosi, M. A.
  • Georgiou, Tk
  • Stevens, Mm
  • Aviles Milan, J.
  • Chung, Jj
  • Attallah, Moataz M.
  • Paraskevoulakos, Charilaos
  • Pavier, Mj
  • Gu, Huaiyuan
  • Shterenlikht, Anton
  • Barrioni, Br
  • Naruphontjirakul, P.
  • Norris, E.
  • Pereira, Mdm
  • Gumbsch, P.
  • Pastewka, L.
  • Lewis, M. P.
  • Capel, A. J.
  • Rimington, R. P.
  • Smith, J. A.
  • Kruk, R.
  • Hahn, H.
  • Chellali, M. R.
  • Nandam, S. H.
  • Boll, T.
  • Fawey, M. H.
  • Velasco, L.
  • Moreno-Pineda, E.
  • Zahedi, A.
  • Jones, D. S.
  • Madi, A. M.
  • Gilvary, G. C.
  • Almajaan, A.
  • Loys, Z. Senta
  • Kelleher, J. F.
  • Healy, A. M.
  • Andrews, G. P.
  • Tian, Yiwei
  • Aymonier, Cyril
  • Howell, Irene R.
  • Giroire, Baptiste
  • Watkins, James J.
  • Garcia, Alain
  • Russell, A. R.
  • Muir Wood, D.
  • Liu, Y.
  • Fernandez, J. W.
  • Stapley, S.
  • Zeybek, B.
  • Lowdell, M.
  • Zani, L.
  • Belushi, H. K. Al
  • Radermacher, A.
  • Pham, V. C.
  • Gerard, Sébastien
  • Jacquemin, M.
  • Maçon, Alb
  • Hanna, Jv
  • Bertazzo, S.
  • Page, Sj
  • Chakrabartty, J.
  • Nechache, R.
  • Rosei, F.
  • Harnagea, C.
  • Rousset, J. L.
  • Aouine, M.
  • Farrusseng, D.
  • Tuel, A.
  • Burel, L.
  • Morfin, F.
  • Meunier, Frédéric
  • Abdel-Wahab, A.
  • Demirci, E.
  • Riedel, C.
  • Zimmermann, E. A.
  • Wang, M.
  • Gao, X.
  • Busse, B.
  • Huang, W.
  • Serpone, N.
  • Alotaibi, B.
  • Mi, Z.
  • Lin, L.
  • Kosel, Jürgen
  • Yassine, Omar
  • Pirmoradi, F. N.
  • Zaher, Amir
  • Wolf, K. T.
  • Honarmandi, P.
  • Rivera-Diaz-Del-Castillo, P. E. J.
  • Arróyave, R.
  • Aquino, C.
  • Rousset, J.
  • Besson, L.
  • Roy, A.
  • Babitsky, V.
  • Arroyave, R.
  • Karaman, I.
  • Zhu, R.
  • Maier, H. J.
  • Niendorf, Thomas
  • Stoclet, G.
  • Seguela, Roland
  • Lefebvre, J. M.
  • Vert, Michel
  • Vinogradov, A.
  • Inoue, A.
  • Louzguine-Luzgin, D. V.
  • Xie, Gaogang
  • Yavari, A. R.
  • Kawashima, A.
  • Pelletier, Jean-Marc
  • Huang, Chung-Che
  • Hewak, Daniel W.
  • Sámson, Z. L.
  • Gholipour, B.
  • Macdonald, Kevin
  • Knight, K. J.
  • Lazarev, A.
  • Yokoyama, Y.
OrganizationsLocationPeople

article

A Comparative Study between Hot-Melt Extrusion and Spray-Drying for the Manufacture of Anti-Hypertension Compatible Monolithic Fixed-Dose Combination Products

  • Jones, D. S.
  • Madi, A. M.
  • Gilvary, G. C.
  • Almajaan, A.
  • Li, S.
  • Loys, Z. Senta
  • Kelleher, J. F.
  • Healy, A. M.
  • Andrews, G. P.
  • Tian, Yiwei
Abstract

The purpose of this work was to investigate the application of different advanced continuous processing techniques (hot melt extrusion and spray drying) to the production of fixed-dose combination (FDC) monolithic systems comprising of hydrochlorothiazide and ramipril for the treatment of hypertension. Identical FDC formulations were manufactured by the two different methods and were characterised using powder x-ray diffraction (PXRD) and modulated differential scanning calorimetry (mDSC). Drug dissolution rates were investigated using a Wood’s apparatus, while physical stability was assessed on storage under controlled temperature and humidity conditions. Interestingly both drugs were transformed into their amorphous forms when spray dried, however, hydrochlorothiazide was determined, by PXRD, to be partially crystalline when hot melt extruded with either polymer carrier (Kollidon® VA 64 or Soluplus®). Hot melt extrusion was found to result in significant degradation of ramipril, however, this could be mitigated by the inclusion of the plasticizer, polyethylene glycol 3350, in the formulation and appropriate adjustment of processing temperature. The results of intrinsic dissolution rate studies showed that hot-melt extruded samples were found to release both drugs faster than identical formulations produced via spray drying. However, the differences were attributable to the surface roughness of the compressed discs in the Wood’s apparatus, rather than solid state differences between samples. After a 60-day stability study spray dried samples exhibited a greater physical stability than the equivalent hot melt extruded samples.

Topics
  • surface
  • polymer
  • amorphous
  • inclusion
  • melt
  • powder X-ray diffraction
  • differential scanning calorimetry
  • wood
  • drying
  • melt extrusion