| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Boone, Matthieu N.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2022Sinchuk et al. Variational and Deep Learning Segmentation of Very-Low-Contrast X-ray Computed Tomography Images of Carbon/Epoxy Woven Composites
- 2022Deep learning segmentation of wood fiber bundles in fiberboardscitations
- 2022Continuous fiber-reinforced aramid/PETG 3D-printed composites with high fiber loading through fused filament fabricationcitations
- 2022Detecting thin adhesive coatings in wood fiber materials with laboratory-based dual-energy computed tomography (DECT)citations
- 2021Geometrical and deep learning approaches for instance segmentation of CFRP fiber bundles in textile compositescitations
- 2020Variational and Deep Learning Segmentation of Very-Low-Contrast X-ray Computed Tomography Images of Carbon/Epoxy Woven Compositescitations
- 20183D printing of high drug loaded dosage forms using thermoplastic polyurethanescitations
- 2016Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffoldscitations
- 2016Structure of cellulose -silica hybrid aerogel at sub-micron scale, studied by synchrotron X-ray tomographic microscopycitations
Places of action
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article
3D printing of high drug loaded dosage forms using thermoplastic polyurethanes
Abstract
It was the aim of this study to develop high drug loaded (> 30%, w/w), thermoplastic polyurethane (TPU)-based dosage forms via fused deposition modelling (FDM). Model drugs with different particle size and aqueous solubility were pre-processed in combination with diverse TPU grades via hot melt extrusion (HME) into filaments with a diameter of 1.75 +/- 0.05 mm. Subsequently, TPU-based filaments which featured acceptable quality attributes (i.e. consistent filament diameter, smooth surface morphology and good mechanical properties) were printed into tablets. The sustained release potential of the 3D printed dosage forms was tested in vitro. Moreover, the impact of printing parameters on the in vitro drug release was investigated. TPU-based filaments could be loaded with 60% (w/w) fine drug powder without observing severe shark skinning or inconsistent filament diameter. During 3D printing experiments, HME filaments based on hard TPU grades were successfully converted into personalized dosage forms containing a high concentration of crystalline drug (up to 60%, w/w). In vitro release kinetics were mainly affected by the matrix composition and tablet infill degree. Therefore, this study clearly demonstrated that TPU-based FDM feedstock material offers a lot of formulation freedom for the development of personalized dosage forms.