| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Van Hoorebeke, Luc
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2023In silico mechanics and TGF-ß expression of stem cells intramyocardially transplanted with a biomaterial injectate for treatment of myocardial infarction
- 2023Pixel-wise beam-hardening correction for dark-field signal in X-ray dual-phase grating interferometrycitations
- 2023Effect of biomaterial stiffness on cardiac mechanics in a biventricular infarcted rat heart model with microstructural representation of in situ intramyocardial injectatecitations
- 2022Detecting thin adhesive coatings in wood fiber materials with laboratory-based dual-energy computed tomography (DECT)citations
- 20183D printing of high drug loaded dosage forms using thermoplastic polyurethanescitations
- 2016Finite element simulation of the woven geometry and mechanical behaviour of a 3D woven dry fabric under tensile and shear loading using the digital element methodcitations
- 2015A Micro-Computed Tomography Technique to Study the Quality of Fibre Optics Embedded in Composite Materialscitations
- 2015Autogenous healing of cementitious materials promoted by superabsorbent polymers studied by means of X-ray computed microtomography
Places of action
| Organizations | Location | People |
|---|
article
3D printing of high drug loaded dosage forms using thermoplastic polyurethanes
Abstract
It was the aim of this study to develop high drug loaded (> 30%, w/w), thermoplastic polyurethane (TPU)-based dosage forms via fused deposition modelling (FDM). Model drugs with different particle size and aqueous solubility were pre-processed in combination with diverse TPU grades via hot melt extrusion (HME) into filaments with a diameter of 1.75 +/- 0.05 mm. Subsequently, TPU-based filaments which featured acceptable quality attributes (i.e. consistent filament diameter, smooth surface morphology and good mechanical properties) were printed into tablets. The sustained release potential of the 3D printed dosage forms was tested in vitro. Moreover, the impact of printing parameters on the in vitro drug release was investigated. TPU-based filaments could be loaded with 60% (w/w) fine drug powder without observing severe shark skinning or inconsistent filament diameter. During 3D printing experiments, HME filaments based on hard TPU grades were successfully converted into personalized dosage forms containing a high concentration of crystalline drug (up to 60%, w/w). In vitro release kinetics were mainly affected by the matrix composition and tablet infill degree. Therefore, this study clearly demonstrated that TPU-based FDM feedstock material offers a lot of formulation freedom for the development of personalized dosage forms.