| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ferreira, D.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Cytotoxic leuconoxine-type diazaspiroindole alkaloids isolated from Cryptolepis dubia.citations
- 2019Bio-based materials for food packaging applications
- 2019Multifunctional fibrous structures based on graphene nanoplatelets, chitosan and natural fibres
- 2019Smart green composites reinforced with graphene nanoplatelets and carbon nanotubes
- 2019CBRNe military protection: the potential of natural fibres and metal oxide nanoparticles
- 2019Multifunctional flax fibres based on the combined effect of silver and zinc oxide (Ag/ZnO) nanostructures
- 2019Applications of nanocellulose: Review and future perspectives
- 2019Biodegradable films reinforced with cellulose nanocrystals and natural extracts for food packing applications
- 2019Development of Chitosan-Gelatin nanofibers with cellulose nanocrystals for wound dressing applications
- 2019Electrospun natural nanofibres with bioactive plant extracts for therapeutic applications
- 2019Smart natural fibers based on graphene nanoplatelets and biodegradable polymers
- 2018Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeabilitycitations
- 2018Mucoadhesive chitosan-coated solid lipid nanoparticles for better management of tuberculosiscitations
- 2018Soldier monitoring systems: the potential of natural fibres and metal oxide nanoparticles
- 2016Design and statistical modeling of mannose-decorated dapsone-containing nanoparticles as a strategy of targeting intestinal M-cellscitations
Places of action
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article
Mucoadhesive chitosan-coated solid lipid nanoparticles for better management of tuberculosis
Abstract
Taking into consideration the potential mucoadhesion properties of systems in lung delivery, this paper describes the preparation and characterization of chitosan-coated solid lipid nanoparticles (C-SLNs) loaded with rifampicin (RIF) as anti-tuberculosis (anti-TB) drug. The process of development and characterization of the NPs in terms of size, surface charge, encapsulation efficiency (EE), morphology, in vitro drug release, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), in vitro assessment of mucoadhesive property, cell viability and permeability studies are documented. Results showed that the SLNs had a smooth spherical shape with a size of ca. 245-344 nm and with a zeta potential around -30 mV for SLNs and +40 mV for C-SLNs. The surface charge variation from negative to positive charge and FTIR analysis demonstrated the successful process of coating the nanoparticles (NPs) surface with chitosan. The DSC thermograms were in agreement with the nanostructure of the SLNs. The EE of drug was found to be higher than 90% and the loading capacity (LC) around 4.5%. C-SLNs show higher in vitro muchoadesive properties and a higher permeability in alveolar epithelial cells A549 than uncoated SLNs, indicating that the developed C-SLNs can be used as a promising carrier for sasfer and efficient management of TB.