| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bills, Paul
University of Huddersfield
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2024Trueness of vat-photopolymerization printing technology of interim fixed partial denture with different building orientationcitations
- 2021Comparison and appraisal of techniques for the determination of material loss from tapered orthopaedic surfacescitations
- 2020Challenges in Inspecting Internal Features for SLM Additive Manufactured Build Artifactscitations
- 2020The Detection of Unfused Powder in EBM and SLM Additive Manufactured Componentscitations
- 2020Development of an Additive Manufactured Artifact to Characterize Unfused Powder Using Computed Tomographycitations
- 2019The challenges in edge detection and porosity analysis for dissimilar materials additive manufactured components
- 2018Optimization of surface determination strategies to enhance detection of unfused powder in metal additive manufactured components
- 2018Development of an AM artefact to characterize unfused powder using computer tomography
- 2018Characterisation of powder-filled defects in additive manufactured surfaces using X-ray CT
- 2017The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tabletscitations
- 2017Results from an interlaboratory comparison of areal surface texture parameter extraction from X-ray computed tomography of additively manufactured parts
- 2017Method for characterizing defects/porosity in additive manufactured components using computer tomography
- 2016Method for Characterization of Material Loss from Modular Head-Stem Taper Surfaces of Hip Replacement Devicescitations
- 2006The use of CMM techniques to assess the wear of total knee replacements
Places of action
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article
The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets
Abstract
Co-administration of drugs with alcohol can affect the plasma concentration of drugs in patients. It is also known that the excipients used in the formulation of drugs may not always be resistant to alcohol. This study evaluates effect of varying alcohol concentrations on theophylline release from two grades of Grewia mollis polysaccharides. X-ray microtomography showed that native polysaccharide formulation compacts were not homogenous after the mixing process resulting in its failure in swelling studies. Removal of starch from the native polysaccharide resulted in homogenous formulation compacts resistant to damage in high alcoholic media in pH 6.8 (40%v/v absolute ethanol). Destarched polymer compacts had a significantly higher hardness (375 N) than that of the native polysaccharide (82 N) and HPMC K4 M (146 N). Dissolution studies showed similarity at all levels of alcohol tested (f2 = 57-91) in simulated gastric media (pH 1.2). The dissolution profiles in the simulated intestinal fluids were also similar (f2 = 60-94), with the exception of the native polysaccharide in pH 6.8 (40%v/v absolute ethanol) (f2 = 43). This work highlights the properties of Grewia polysaccharide as a matrix former that can resist high alcoholic effects therefore; it may be suitable as an alternative to some of the commercially available matrix formers with wider applications for drug delivery as a cheaper alternative in the developing world.