| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Asare-Addo, Kofi
University of Huddersfield
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2021Magnesium Aluminium Silicate-Metformin Hydrochloride Complexes - The Use of Isothermal Calorimetry for Probing Clay and Drug Nanocomplexations
- 2020Thermodynamics of clay – Drug complex dispersionscitations
- 2020An investigation into the use of low quantities of functional additives to control drug release from hot melt extruded solid dispersions for poorly soluble drug deliverycitations
- 2020A molecular understanding of magnesium aluminium silicate – drug, drug - polymer, magnesium aluminium silicate - polymer nanocomposite complex interactions in modulating drug releasecitations
- 2020Use of thermodynamics in understanding drug release from xanthan gum matricescitations
- 2020Imaging of the Effect of Alcohol-Containing Media on the Performance of Hypromellose Hydrophilic Matrix Tablets: Comparison of Direct Compression and Regular Grades of Polymercitations
- 2020Drug release from magnesium aluminium silicate-polyethylene oxide (PEO) nanocomposite matricescitations
- 2019Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersionscitations
- 2019Real time calorimetric characterisation of clay–drug complex dispersions and particlescitations
- 2019Hot-melt extrusion process impact on polymer choice of glyburide solid dispersionscitations
- 2017The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tabletscitations
- 2016An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepinecitations
- 2013The influence of agitation sequence and ionic strength on in vitro drug release from hypromellose (E4M and K4M) ER matrices--the use of the USP III apparatus.citations
Places of action
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article
The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets
Abstract
Co-administration of drugs with alcohol can affect the plasma concentration of drugs in patients. It is also known that the excipients used in the formulation of drugs may not always be resistant to alcohol. This study evaluates effect of varying alcohol concentrations on theophylline release from two grades of Grewia mollis polysaccharides. X-ray microtomography showed that native polysaccharide formulation compacts were not homogenous after the mixing process resulting in its failure in swelling studies. Removal of starch from the native polysaccharide resulted in homogenous formulation compacts resistant to damage in high alcoholic media in pH 6.8 (40%v/v absolute ethanol). Destarched polymer compacts had a significantly higher hardness (375 N) than that of the native polysaccharide (82 N) and HPMC K4 M (146 N). Dissolution studies showed similarity at all levels of alcohol tested (f2 = 57-91) in simulated gastric media (pH 1.2). The dissolution profiles in the simulated intestinal fluids were also similar (f2 = 60-94), with the exception of the native polysaccharide in pH 6.8 (40%v/v absolute ethanol) (f2 = 43). This work highlights the properties of Grewia polysaccharide as a matrix former that can resist high alcoholic effects therefore; it may be suitable as an alternative to some of the commercially available matrix formers with wider applications for drug delivery as a cheaper alternative in the developing world.