Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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Materials Map under construction

The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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King's College London

in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (6/6 displayed)

  • 2020Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA) Microcrystalline Solid Dispersion Films9citations
  • 2019Engineering Biomimetic Gelatin Based Nanostructures as Synthetic Substrates for Cell Culture9citations
  • 2018The development of progesterone-loaded nanofibers using pressurized gyration50citations
  • 2016Development of micro-fibrous solid dispersions of poorly water-soluble drugs in sucrose using temperature-controlled centrifugal spinning79citations
  • 2016Solid microcrystalline dispersion films as a new strategy to improve the dissolution rate of poorly water soluble drugs26citations
  • 2015Making nanofibres of mucoadhesive polymer blends for vaginal therapies43citations

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Chart of shared publication
Mohac, Laura Modica De
2 / 2 shared
Al-Sahaf, Zahra
1 / 1 shared
Licciardi, Mariano
1 / 6 shared
Pazhanimala, Shaleena
1 / 1 shared
Vllasaliu, Driton
1 / 1 shared
Craig, Duncan Q. M.
3 / 14 shared
Brako, Francis
2 / 5 shared
Mahalingam, Suntharavathanan
2 / 6 shared
Edirisinghe, Mohan
2 / 21 shared
Missaghi, Shahrzad
1 / 1 shared
Marano, Stefania
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Barker, Susan Anne
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Rajabi-Siahboomi, Ali
1 / 3 shared
Pina, Maria De Fátima
1 / 1 shared
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Co-Authors (by relevance)

  • Mohac, Laura Modica De
  • Al-Sahaf, Zahra
  • Licciardi, Mariano
  • Pazhanimala, Shaleena
  • Vllasaliu, Driton
  • Craig, Duncan Q. M.
  • Brako, Francis
  • Mahalingam, Suntharavathanan
  • Edirisinghe, Mohan
  • Missaghi, Shahrzad
  • Marano, Stefania
  • Barker, Susan Anne
  • Rajabi-Siahboomi, Ali
  • Pina, Maria De Fátima
OrganizationsLocationPeople

article

Solid microcrystalline dispersion films as a new strategy to improve the dissolution rate of poorly water soluble drugs

  • Mohac, Laura Modica De
  • Pina, Maria De Fátima
  • Raimi-Abraham, Bt
Abstract

<p>In this study, we evaluate the dissolution rate enhancement of solid microcrystalline dispersion (SMD) films of olanzapine (OLZ) formulated with four water-soluble polymers namely poly(N-vinylpyrrolidone) (PVP), poloxamer 188 (P188), poloxamer 407 (P407) and Soluplus<sup>®</sup> (SLP). Prepared formulations were characterised to determine particle size, morphology, hydrogen bonding interactions, thermal characteristics as well as in vitro dissolution studies conducted under sink conditions (pH 6.8). Particle size of OLZ in all formulations ranged between 42 and 58 μm. Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR), Differential Scanning Calorimetry (DSC) and Hot-Stage Microscopy (HSM) studies confirmed OLZ was well maintained in its crystalline state during the formulation process. In vitro dissolution studies showed immediate drug release from all formulation when compared to the drug alone. The greatest increase in in vitro dissolution rate was observed in formulations containing P188 most likely due to its enhanced hydrophilic and surfactant properties compared to the other agents used. Overall, this study successfully generated OLZ loaded SMD films with improved in vitro dissolution rates which is highly likely to result in improved oral bioavailability in vivo.</p>

Topics
  • impedance spectroscopy
  • morphology
  • dispersion
  • polymer
  • Hydrogen
  • differential scanning calorimetry
  • Fourier transform infrared spectroscopy
  • surfactant
  • microscopy