| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Lamprou, Dimitrios A.
Queen's University Belfast
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (22/22 displayed)
- 2023Combining microfluidics and coaxial 3D-bioprinting for the manufacturing of diabetic wound healing dressingscitations
- 2023Combining microfluidics and coaxial 3D-bioprinting for the manufacturing of diabetic wound healing dressingscitations
- 2023Urethane dimethacrylate-based photopolymerizable resins for stereolithography 3D printing: a physicochemical characterisation and biocompatibility evaluationcitations
- 20223D bioprinted scaffolds for diabetic wound healing applicationscitations
- 2022Stereolithography 3D printed implants: a preliminary investigation as potential local drug delivery systems to the earcitations
- 2022High spatial resolution ToF-SIMS imaging and image analysis strategies to monitor and quantify early phase separation in amorphous solid dispersionscitations
- 2022Fused deposition modeling 3D printing proof of concept study for personalised inner ear therapycitations
- 2021Fused deposition modelling for the development of drug loaded cardiovascular prosthesiscitations
- 2021Microfluidics Technology for the Design and Formulation of Nanomedicinescitations
- 2021Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular graftscitations
- 2021Microfluidics technology for the design and formulation of nanomedicinescitations
- 20203D printing of drug-loaded thermoplastic polyurethane meshes: A potential material for soft tissue reinforcement in vaginal surgerycitations
- 20193D printed microneedle patches using stereolithography (SLA) for intradermal insulin deliverycitations
- 2017Fabrication and characterisation of drug-loaded electrospun polymeric nanofibers for controlled release in hernia repaircitations
- 2017A novel methodology to study polymodal particle size distributions produced during continuous wet granulationcitations
- 2017Probing polydopamine adhesion to protein and polymer films : microscopic and spectroscopic evaluation
- 2017Isatin thiosemicarbazones promote honeycomb structure formation in spin-coated polymer films: concentration effect and release studiescitations
- 2017Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluationcitations
- 2016A novel hot-melt extrusion formulation of albendazole for increasing dissolution propertiescitations
- 2016Isatin thiosemicarbazone-blended polymer films for biomedical applications : surface morphology, characterisation and preliminary biological assessmentcitations
- 2014The degradative effects of germicidal light on flexible endoscope material
- 2012Polymer templating of supercooled indomethacin for polymorph selectioncitations
Places of action
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article
A novel hot-melt extrusion formulation of albendazole for increasing dissolution properties
Abstract
<p>The main aim of the research focused on the production of hot-melt extrusion (HME) formulations with increased dissolution properties of albendazole (ABZ). Therefore, HME was applied as a continuous manufacturing technique to produce amorphous solid dispersions of the poorly water soluble drug ABZ combined with the polymer matrix polyvinylpyrrolidone PVP K12. HME formulations of ABZ-PVP K12 comprised a drug content of 1%, 5% and 10% w/w. The main analytical characterisation techniques used were scanning electron microscopy (SEM), micro-computed tomography (μ-CT), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and dissolution profile studies. The application of SEM, XRPD and DSC evidenced drug physical transformation from crystalline to amorphous state and therefore, the achievement of an amorphous solid dispersion. The introduction of a novel technique, μ-CT, to characterise the internal structure of these materials revealed key information regarding materials distribution and void content. Dissolution profile studies evidenced a high increase in drug release profile compared to pure ABZ. These promising results can lead to a great enhancement of the oral bioavailability of ABZ dosage forms. Therefore, HME is a potential continuous manufacturing technique to overcome ABZ poor solubility properties and lead to a significant increase in the therapeutic effect.</p>