| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Tsibouklis, John
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (24/24 displayed)
- 2020Inkjet printing of a thermolabile model drug onto FDM-printed substrates: formulation and evaluationcitations
- 2015An evaluation of the adhesion of solid oral dosage form coatings to the oesophaguscitations
- 2015An evaluation of the adhesion of solid oral dosage form coatings to the oesophaguscitations
- 2013Nanocomposites based on copolymers of fluorinated imide and polyhedral oligomeric silsesquioxane macromonomer: microstructure and morphology studiescitations
- 2011Multifunctional poly(alkyl methacrylate) films for dental carecitations
- 2011Mapping surface heterogeneity: the AFM-based approach
- 2011Ring opening metathesis polymerization of polyoctahedral oligomeric silsesquioxanes (POSS) incorporated oxanorbornene-5,6-dicarboximide: synthesis, characterization, and surface morphology of copolymerscitations
- 2011The effects of incorporated silicone oils and calcium carbonate on the resistance to settlement and the antifouling performance of a silicone elastomercitations
- 2010A thermogravimetric method for assessing the substantivity of polymer films on dentally relevant substratescitations
- 2010Towards the determination of surface energy at the nanoscale: a further assessment of the AFM-based approachcitations
- 2010A comparative study of surface energy data from atomic force microscopy and from contact angle goniometrycitations
- 2008Synthesis and characterization of low surface energy fluoropolymers as potential barrier coatings in oral carecitations
- 2004Friction coefficient mapping using the atomic force microscopecitations
- 2003Ultra-low surface energy polymerscitations
- 2002Poly(di-1H,1H,2H,2H-perfluoroalkylitaconate) filmscitations
- 2002Fluoropolymer coatings with inherent resistance to biofouling
- 2002Adhesion force mapping of polymer surfaces: factors influencing force of adhesioncitations
- 2002Adsorbed poly(ethyleneoxide)–poly(propyleneoxide) copolymers on synthetic surfaces: spectroscopy and microscopy of polymer structures and effects on adhesion of skin-borne bacteriacitations
- 2002A study of pyroelectric and dielectric properties of alternate layer fluorodeconoylmonoitaconate Langmuir-Blodgett filmscitations
- 2002Impact of Fluorination and Side-Chain Length on Poly(methylpropenoxyalkylsiloxane) and Poly(alkyl methacrylate) Solubility in Supercritical Carbon Dioxidecitations
- 2002Poly(di-1H,1H,2H,2H-perfluoroalkylitaconate) films:surface organisation phenomena, surface energy determinations and force of adhesion measurementscitations
- 2001Nanoindentation and adhesion-force-mapping studies of polymer blend films
- 2000Mapping the surface heterogeneity of a polymer blend: an adhesion-force-distribution study using the Atomic Force Microscopecitations
- 2000Poly(perfluoroalkyl methacrylate) film structures: surface organization phenomena, surface energy determinations, and force of adhesion measurementscitations
Places of action
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article
An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus
Abstract
<p>There is a requirement for the development of oral dosage forms that are adhesive and allow extended oesophageal residence time for localised therapies, or are non-adhesive for ease of swallowing. This study provides an initial assessment of the in vitro oesophageal retention characteristics of several widely utilised pharmaceutical coating materials. To this end, a previously described apparatus has been used to measure the force required to pull a coated disc-shaped model tablet across a section of excised oesophageal tissue. Of the materials tested, the well-studied mucoadhesive polymer sodium alginate was found to be associated with significant oesophageal adhesion properties that was capable of 'self-repairing'. Hydroxypropylmethylcellulose exhibited less pronounced bioadhesive behaviour and blending this with plasticiser or with low molecular weight polymers and surfactants did not significantly affect this. Low molecular weight water soluble polymers, were found to behave similarly to the uncoated glass control disc. Polysorbates exhibited bioadhesion behaviour that was majorly influenced by the nature of the surfactant. The insoluble polymer ethylcellulose, and the relatively lipophilic surfactant sorbitan monooleate were seen to move more readily than the uncoated disc, suggesting that these may have a role as 'easy-to-swallow' coatings.</p>