Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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Materials Map under construction

The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (1/1 displayed)

  • 2009Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets52citations

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Chart of shared publication
Gordon, Keith C.
1 / 14 shared
Muschert, Susanne
1 / 1 shared
Cuppok, Yvonne
1 / 1 shared
Rades, Thomas
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Pepper, Michael
1 / 3 shared
Taday, Philip F.
1 / 1 shared
Siepmann, Florence
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Shen, Yaochun
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Siepmann, Juergen
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Chart of publication period
2009

Co-Authors (by relevance)

  • Gordon, Keith C.
  • Muschert, Susanne
  • Cuppok, Yvonne
  • Rades, Thomas
  • Pepper, Michael
  • Taday, Philip F.
  • Siepmann, Florence
  • Shen, Yaochun
  • Siepmann, Juergen
OrganizationsLocationPeople

article

Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets

  • Gordon, Keith C.
  • Muschert, Susanne
  • Cuppok, Yvonne
  • Ho, Louise
  • Rades, Thomas
  • Pepper, Michael
  • Taday, Philip F.
  • Siepmann, Florence
  • Shen, Yaochun
  • Siepmann, Juergen
Abstract

Film coating thickness and terahertz electric field peak strength (TEFPS) were determined using terahertz pulsed imaging (TPI) and employed for the analysis of sustained-release coated pellets (theophylline layered sugar cores coated with Kollicoat SR:Kollicoat IR polymer blends). The effects of coating thickness, drug layer uniformity and optional curing were investigated using eight batches of pellets. Ten pellets from each batch were imaged with TPI to analyse the coating morphology (depicted in TEFPS) and thickness prior to release measurements. The results showed TEFPS values of 15.8% and 14.5% for pellets with a smooth drug layer coated at 8.2 and 12.5% (w/w) polymer weight-gain, respectively. Whereas 6.7% was derived for pellets with a coarse drug layer coated at both weight-gains. Although there were major differences in TEFPS, the resulting drug release kinetics were very similar. It was also shown that a 36 microm coating thickness difference was not drug release rate determining. These results suggested that drug release for the pellets studied was not predominately governed by drug diffusion through the polymeric film coating but probably to a large extent limited by drug solubility. TPI proved to be highly suitable to detect non-homogeneities in the drug layer and polymeric film coating.

Topics
  • strength
  • layered
  • curing
  • polymer blend