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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Geever, Luke
Technological University of the Shannon: Midlands Midwest
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (31/31 displayed)
- 2023Synthesis of NVCL-NIPAM hydrogels using PEGMA as a chemical crosslinker for controlled swelling behaviours in potential shapeshifting applicationscitations
- 2023Micro-Injection Moulding of PEO/PCL Blend–Based Matrices for Extended Oral Delivery of Fenbendazolecitations
- 2023Compatibility Study Between Fenbendazole and Poly(Ethylene Oxide) with Application in Solid Dispersion Formulations Using Hot-Melt Extrusioncitations
- 2022Compatibility Study between Fenbendazole and Polymeric Excipients Used in Pharmaceutical Dosage Forms Using Thermal and Non-Thermal Analytical Techniquescitations
- 2020Effect of electron beam irradiation on the rheological properties and phase transition temperature of poly(N-vinylcaprolactam)
- 2018Surface-modified halloysite nanotubes reinforced poly(lactic acid) for use in biodegradable coronary stentscitations
- 2018Degradable nanocomposites for fused filament fabrication applicationscitations
- 2017Halloysite nanotube reinforced polylactic acid compositecitations
- 2016Synthesis and characterization of high density polyethylene/peat ash compositescitations
- 2016Chemical surface modification of calcium carbonate particles with stearic acid using different treating methodscitations
- 2016Melt Extruded Bioresorbable Polymer Composites for Potential Regenerative Medicine Applicationscitations
- 2016The effect of the mixing routes of biodegradable polylactic acid and polyhydroxybutyrate nanocomposites and compatibilised nanocompositescitations
- 2015Thermal Degradation of Bio-nanocompositescitations
- 2014The effect of processing conditions for polylactic acid based fibre composites via twin-screw extrusioncitations
- 2014Effect of Compatibilizer Content on the Mechanical Properties of Bioplastic Composites via Hot Melt Extrusioncitations
- 2014Improvement in mechanical properties of grafted polylactic acid composite fibers via hot melt extrusioncitations
- 2014Melt Processing of Bioplastic Composites via Twin Screw Extrusion and Injection Moldingcitations
- 2014Smart thermosensitive poly (N-vinylcaprolactam) based hydrogels for biomedical applications.
- 2013Mechanical and biodegradation performance of short natural fibre polyhydroxybutyrate compositescitations
- 2011Assessing the effect of selected photoinitiators on the properties of photopolymerised temperature sensitive hydrogels
- 2010Physical and mechanical properties of blends based on poly (dl-lactide), poly (l-lactide-glycolide) and poly (ε-caprolactone)citations
- 2010In vitro degradation and drug release from polymer blends based on poly(dl-lactide), poly(l-lactide-glycolide) and poly(ε-caprolactone)citations
- 2010Characterisation of the effects of a titanium micro particle filler on a polyether-block-amide host matrixcitations
- 2009Development and characterisation of an agar-polyvinyl alcohol blend hydrogelcitations
- 2008Characterisation and controlled drug release from novel drug-loaded hydrogelscitations
- 2007The effect of salts and pH buffered solutions on the phase transition temperature and swelling of thermoresponsive pseudogels based on N-isopropylacrylamidecitations
- 2007Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion processcitations
- 2007The incorporation of an organically modified layered silicate in monolithic polymeric matrices produced using hot melt extrusioncitations
- 2007The synthesis, swelling behaviour and rheological properties of chemically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
- 2006The use of Agar as a novel filler for monolithic matrices produced using hot melt extrusioncitations
- 2006Lower critical solution temperature control and swelling behaviour of physically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
Places of action
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article
Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion process
Abstract
<p>The use of supercritical fluids as plasticisers in polymer processing has been well documented. The body of work described in this research paper outlines the use of a supercritical CO<sub>2</sub> assisted extrusion process in the preparation of a hot melt extruded monolithic polymer matrix for oral drug delivery. Several batches of matrix material were prepared with Carvedilol used as the active pharmaceutical ingredient (API). These batches were subsequently extruded both with and without supercritical CO<sub>2</sub> incorporation. The resultant matrices were characterised using steady-state parallel plate rheometry, differential scanning calorimetry (DSC), atomic force microscopy (AFM), micro-thermal analysis (μTA) and dissolution testing. Dissolution analysis showed that the use of supercritical CO<sub>2</sub> during the extrusion process resulted in a faster dissolution of API when compared with unassisted extrusion. The supercritical CO<sub>2</sub> incorporation also resulted in reduced viscosity during processing, therefore allowing for quicker throughput and productivity. The results detailed within this paper indicate that supercritical fluid assisted hot melt extrusion is a viable enhancement to conventional hot melt extrusion for the production of monolithic dosage forms.</p>