| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Wang, Dong
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2024Engineered Anchor Peptide LCI with a Cobalt Cofactor Enhances Oxidation Efficiency of Polystyrene Microparticlescitations
- 2024Hydrogen diffusivity in X65 pipeline steel: Desorption and permeation studiescitations
- 2024Low-temperature process design for inversion mode n-channel thin-film-transistor on polycrystalline Ge formed by solid-phase crystallizationcitations
- 2024Controllable Si oxidation mediated by annealing temperature and atmosphere
- 2024Safe pipelines for hydrogen transportcitations
- 2024Integration of Multijunction Absorbers and Catalysts for Efficient Solar‐Driven Artificial Leaf Structures: A Physical and Materials Science Perspectivecitations
- 2023Gold nanosponges: fascinating optical properties of a unique disorder-dominated systemcitations
- 2022A dual functional chondro-inductive chitosan thermogel with high shear modulus and sustained drug release for cartilage tissue engineeringcitations
- 2022Controllable Si oxidation mediated by annealing temperature and atmospherecitations
- 2022Thin film nanostructuring at oblique angles by substrate patterning
- 2021Rapid fabrication and interface structure of highly faceted epitaxial Ni-Au solid solution nanoparticles on sapphirecitations
- 2019Investigation of a surface mounted pm machine concept with 3d-flux paths, modular stator and amorphous materialcitations
- 2018The effect of in-situ hydrogen plasma charging on the hydrogen embrittlement susceptibility of DP and TRIP steel
- 2016Solid-state dewetting of single- and bilayer Au-W thin films: unraveling the role of individual layer thickness, stacking sequence and oxidation on morphology evolutioncitations
- 2014A highly active and magnetically recoverable tris(triazolyl)-CuI catalyst for alkyne-azide cycloaddition reactionscitations
- 2013Nuclear resonance vibrational spectroscopic and computational study of high-valent diiron complexes relevant to enzyme intermediates.citations
- 2005Polymerization and carbonization of high internal phase emulsionscitations
Places of action
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article
A dual functional chondro-inductive chitosan thermogel with high shear modulus and sustained drug release for cartilage tissue engineering
Abstract
We report a chitosan-based nanocomposite thermogel with superior shear modulus resembling that of cartilage and dual pro-chondrogenic and anti-inflammatory functions. Two therapeutic agents, kartogenin (KGN) and diclofenac sodium (DS), are employed to promote chondrogenesis of stem cells and suppress inflammation, respectively. To extend the release time in a controlled manner, KGN is encapsulated in the uniform-sized starch microspheres and DS is loaded into the halloysite nanotubes. Both drug carriers are doped into the maleimide-modified chitosan hydrogel to produce a shear modulus of 167 ± 5 kPa that is comparable to that of articular cartilage (50–250 kPa). Owing to the hydrogel injectability and relatively suitable gelation time (5 ± 0.5 min) at 37 °C, this system potentially constitutes a manageable platform for clinical practice. Moreover, sustained linear drug release for over a month boosts chondro-differentiation of stem cells to eliminate the necessity for multiple administrations. Considering virtues such as thermogel strength and ability to co-deliver anti-inflammatory and chondro-inductive biomolecules continuously, the materials and strategy have promising potential in functional cartilage tissue engineering.