| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ren, Guogang
University of Hertfordshire
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (22/22 displayed)
- 2024Enhanced photocatalytic degradation of diazinon using Ni:ZnO/Fe3O4 nanocomposite under solar lightcitations
- 2024Structural and thermal analyses in semiconducting and metallic zigzag single-walled carbon nanotubes using molecular dynamics simulationscitations
- 2024Structural and thermal analyses in semiconducting and metallic zigzag single-walled carbon nanotubes using molecular dynamics simulations
- 2023Exploring mesoporous silica nanoparticles as oral insulin carriers: In-silico and in vivo evaluationcitations
- 2021Exploiting the antiviral potential of intermetallic nanoparticlescitations
- 2021Antiviral Efficacy of Metal and Metal Oxide Nanoparticles against the Porcine Reproductive and Respiratory Syndrome Viruscitations
- 2021Mechanical properties of 3-D printed truss-like lattice biopolymer non-stochastic structures for sandwich panels with natural fibre composite skins
- 2020Comparative Study of the Antimicrobial Effects of Tungsten Nanoparticles and Tungsten Nanocomposite Fibres on Hospital Acquired Bacterial and Viral Pathogenscitations
- 2019Co-Culture of Keratinocyte-Staphylococcus aureus on Cu-Ag-Zn/CuO and Cu-Ag-W Nanoparticle Loaded Bacterial Cellulose:PMMA Bandagescitations
- 2019Mechanical properties of 3-D printed truss-like lattice biopolymer non-stochastic structures for sandwich panels with natural fibre composite skinscitations
- 2019A scale-up of energy-cycle analysis on processing non-woven flax/PLA tape and triaxial glass fibre fabric for composites
- 2019A scale-up of energy-cycle analysis on processing non-woven flax/PLA tape and triaxial glass fibre fabric for compositescitations
- 2019Synergistic Antibacterial Effects of Metallic Nanoparticle Combinationscitations
- 2018Co-Culture of Keratinocyte-Staphylococcus aureus on Cu-Ag-Zn/CuO and Cu-Ag-W Nanoparticle Loaded Bacterial Cellulose:PMMA Bandagescitations
- 2017Characterisation of chemical composition and structural features of novel antimicrobial nanoparticlescitations
- 2012Mechanical properties of glass silicate based composites : effects of varying fibre volume fractions
- 2012Antimicrobial properties of electrically formed elastomeric polyurethane–copper oxide nanocomposites for medical and dental applicationscitations
- 2012Mechanical properties of glass silicate based compositescitations
- 2010Hemp fibre as alternative to glass fibre in sheet moulding compound. Part 1 : influence of fibre content and surface treatment on mechanical properties
- 2008Determination of the complex permittivity of textiles and leather in the 14-40 mm wave band using a free-wave transmittance only method
- 2007Mechanical properties of carbon-fibre reinforced silicate matrix compositescitations
- 2004Low cost ceramic moulding compositescitations
Places of action
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document
Exploring mesoporous silica nanoparticles as oral insulin carriers: In-silico and in vivo evaluation
Abstract
© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives CC BY-NC-ND licence, https://creativecommons.org/licenses/by-nc-nd/4.0/ ; The advancements in nanoscience have brought attention to the potential of utilizing nanoparticles as carriers for oral insulin administration. This study aims to investigate the effectiveness of synthesized polymeric mesoporous silica nanoparticles (MSN) as carriers for oral insulin and their interactions with insulin and IR through in-silico docking. Diabetic rats were treated with various MSN samples, including pure MSN, Amin-grafted MSN/PEG/Insulin (AMPI), Al-grafted MSN/PEG/Insulin (AlMPI), Zinc-grafted MSN/PEG/Insulin (ZNPI), and Co-grafted MSN/PEG/Insulin (CMPI). The nanocomposites were synthesized using a hybrid organic-inorganic method involving MSNs, graphene oxide, and insulin. Characterization of the nanocomposites was conducted using X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM). In vivo tests included the examination of blood glucose levels and histopathological parameters of the liver and pancreas in type 1 diabetic rats. The MSN family demonstrated a significant reduction in blood glucose levels compared to the diabetic control group (p < 0.001). The synthesized nanocomposites exhibited safety, non-toxicity, fast operation, self-repairing pancreas, cost-effectiveness, and high efficiency in the oral insulin delivery system. In the in-silico study, Zn-grafted MSN, Co-grafted MSN, and Al-grafted MSN were selected. Docking results revealed strong interactions between MSN compounds and insulin and IR, characterized by the formation of hydrogen bonds and high binding energy. Notably, Co-grafted MSN showed the highest docking scores of -308.171 kcal/mol and -337.608 kcal/mol to insulin and IR, respectively. These findings demonstrate the potential of polymeric MSN as effective carriers for oral insulin, offering ...