Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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Materials Map under construction

The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (2/2 displayed)

  • 2021The effect of retinal scaffold modulus on performance during surgical handling.12citations
  • 2016Organically linked iron oxide nanoparticle supercrystals with exceptional isotropic mechanical properties154citations

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Rj, Wendland
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Russell, Stephen
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Tucker, Budd
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La, Wiley
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Han, Ian
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2016

Co-Authors (by relevance)

  • Rj, Wendland
  • Russell, Stephen
  • Tucker, Budd
  • Ks, Worthington
  • La, Wiley
  • Han, Ian
  • Kornowski, A.
  • Krekeler, T.
  • Schneider, G. A.
  • Stierle, A.
  • Noei, H.
  • Meyer, A.
  • Abetz, V.
  • Weller, H.
  • Feld, A.
  • Dreyer, A.
  • Yilmaz, E. D.
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article

The effect of retinal scaffold modulus on performance during surgical handling.

  • Rj, Wendland
  • Russell, Stephen
  • Jiao, C.
  • Tucker, Budd
  • Ks, Worthington
  • La, Wiley
  • Han, Ian
Abstract

Emerging treatment strategies for retinal degeneration involve replacing lost photoreceptors using supportive scaffolds to ensure cells survive the implantation process. While many design aspects of these scaffolds, including material chemistry and microstructural cues, have been studied in depth, a full set of design constraints has yet to be established. For example, while known to be important in other tissues and systems, the influence of mechanical properties on surgical handling has not been quantified. In this study, photocrosslinked poly(ethylene glycol) dimethacrylate (PEGDMA) was used as a model polymer to study the effects of scaffold modulus (stiffness) on surgical handling, independent of material chemistry. This was achieved by modulating the molecular weight and concentrations of the PEGDMA in various prepolymer solutions. Scaffold modulus of each formulation was measured using photo-rheology, which enabled the collection of real-time polymerization data. In addition to measuring scaffold mechanical properties, this approach gave insight on polymerization kinetics, which were used to determine the polymerization time required for each sample. Scaffold handling characteristics were qualitatively evaluated using both in vitro and ex vivo trials that mimicked the surgical procedure. In these trials, scaffolds with shear moduli above 35 kPa performed satisfactorily, while those below this limit performed poorly. In other words, scaffolds below this modulus were too fragile for reliable transplantation. To better compare these results with literature values, the compressive modulus was measured for select samples, with the lower shear modulus limit corresponding to roughly 115 kPa compressive modulus. While an upper mechanical property limit was not readily apparent from these results, there was increased variability in surgical handling performance in samples with shear moduli above 800 kPa. Overall, the knowledge presented here provides important groundwork for future studies designed to examine additional retinal scaffold considerations, including the effect of scaffold mechanical properties on retinal progenitor cell fate.

Topics
  • polymer
  • mechanical property
  • molecular weight