| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Wurm, Frederik R.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (42/42 displayed)
- 2024Helical Polyamines
- 2023Copolymerizing Lignin for Tuned Properties of 3D-Printed PEG-Based Photopolymerscitations
- 2023Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarrierscitations
- 2023Water-soluble polyphosphonate-based bottlebrush copolymers via aqueous ring-opening metathesis polymerizationcitations
- 2023The microstructure of polyphosphoesters controls polymer hydrolysis kinetics from minutes to yearscitations
- 2023Real-time 31P NMR reveals different gradient strengths in polyphosphoester copolymers as potential MRI-traceable nanomaterialscitations
- 2023Reversible acetalization of cellulosecitations
- 2023Towards more homogeneous character in 3D printed photopolymers by the addition of nanofillerscitations
- 2022Real-Time 1H and 31P NMR spectroscopy of the copolymerization of cyclic phosphoesters and trimethylene carbonate reveals transesterification from gradient to random copolymerscitations
- 2021Green synthesis and characterization of poly(glycerol-azelaic acid) and its nanocomposites for applications in regenerative medicinecitations
- 2021Facile template preparation of novel electroactive scaffold composed of polypyrrole-coated poly(glycerol-sebacate-urethane) for tissue engineering applicationscitations
- 2021RNA-inspired intramolecular transesterification accelerates the hydrolysis of polyethylene-like polyphosphoesterscitations
- 2021Display of hidden properties of flexible aerogel based on bacterial cellulose/polyaniline nanocomposites with helping of multiscale modelingcitations
- 2020Intrinsic flame retardant phosphonate-based vitrimers as a recyclable alternative for commodity polymers in composite materialscitations
- 2020Developing antibacterial superhydrophobic coatings based on polydimethylsiloxane/silver phosphate nanocompositescitations
- 2020Controlling the biodegradation rates of poly(globalide-co-ε-caprolactone) copolymers by post polymerization modificationcitations
- 2019Matrix matterscitations
- 2019Supercooled Water Drops Do Not Freeze During Impact on Hybrid Janus Particle-Based Surfacescitations
- 2019Copolymerization of Cyclic Phosphonate and Lactide: Synthetic Strategies toward Control of Amphiphilic Microstructurecitations
- 2018Surface-attached poly(phosphoester)-hydrogels with benzophenone groupscitations
- 2018Temperature responsive poly(phosphonate) copolymerscitations
- 2017Poly(alkyl ethylene phosphonate)scitations
- 2017Acid-labile surfactants based on poly(ethyleneglycol), carbon dioxide and propylene oxidecitations
- 2016Fast ultrasound assisted synthesis of chitosan-based magnetite nanocomposites as a modified electrode sensorcitations
- 2016Sequence-Controlled Polymers via Simultaneous Living Anionic Copolymerization of Competing Monomerscitations
- 2016Acid-Labile Amphiphilic PEO-b-PPO-b-PEO Copolymerscitations
- 2016Processing and adjusting the hydrophilicity of poly(oxymethylene) (co)polymerscitations
- 2016Poly(phosphorodiamidate)s by Olefin Metathesis Polymerization with Precise Degradationcitations
- 2016Side-chain poly(phosphoramidate)scitations
- 2015Vinyl ferrocenyl glycidyl ethercitations
- 2014Ferrocene-containing multifunctional polyetherscitations
- 2014Stabilization of nanoparticles synthesized by miniemulsion polymerization using "green" amino-acid based surfactantscitations
- 2013Enlarging the toolboxcitations
- 2013Microstructure analysis of biocompatible phosphoester copolymerscitations
- 2013Ferrocenyl glycidyl ethercitations
- 2013Unsaturated poly(phosphoester)s via ring-opening metathesis polymerizationcitations
- 2012Hyperbranched Polymerscitations
- 2011Rapid access to polyfunctional lipids with complex architecture via oxyanionic ring-opening polymerizationcitations
- 2011PEG-based multifunctional polyethers with highly reactive vinyl-ether side chains for click-type functionalizationcitations
- 2010"Functional poly(ethylene glycol)"citations
- 2008Carbanions on tap - Living anionic polymerization in a microstructured reactorcitations
- 2008Ionic polymerizations in microstructured reactors
Places of action
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article
The microstructure of polyphosphoesters controls polymer hydrolysis kinetics from minutes to years
Abstract
<p>The stability and degradation rates of polymers in aqueous media are critical factors for their biomedical applications, as they must remain intact for a specific period of time before degrading or degrading on-demand to prevent potential accumulation and harmful effects. Polyphosphoesters (PPEs) are highly compatible with biological systems, and the ester bonds in the backbone allow for hydrolytic degradation. In this study, we have demonstrated that the degradation rate of various PPEs can be precisely controlled by minor modifications to the side-chain and the binding pattern around the phosphorous center in the polymer backbone. We synthesized a systematic library of water-soluble PPEs using ring-opening polymerization, resulting in polyphosphates and in-chain or side-chain polyphosphonates. Specifically, we investigated the degradation rates of side-chain polyphosphonates with different side-chain structures (methyl, ethyl, allyl, iso- or n-propyl) at pH = 8 and pH = 11. Our results indicate that the degradation mechanism is influenced by the type and size of the side-chain, as well as the pH. At pH = 11, hydrophilicity is a key factor, while at pH = 8, electron density on the phosphorus is crucial, leading to a random chain scission or a backbiting mechanism. We also observed that changing the binding pattern of the phosphorus or incorporating additional “breaking points” allowed us to tune the half-life times of the polymer from less than a day to several years. This study highlights the versatile stability of water-soluble PPEs, making them a promising option for various applications that require different hydrolysis rates, such as tissue regrowth.</p>