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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Silva, Jorge Carvalho
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2024Preparation and Characterization of Zinc Ferrite and Gadolinium Iron Garnet Composite for Biomagnetic Applicationscitations
- 2024Cryoprotective Polysaccharides with Ordered Gel Structures Induce Ice Growth Anticipation and Survival Enhancement during Cell Cryopreservationcitations
- 2024Bioactive Hydroxyapatite Aerogels with Piezoelectric Particlescitations
- 2023Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillerscitations
- 2023Thermal, Structural, Morphological and Electrical Characterization of Cerium-Containing 45S5 for Metal Implant Coatingscitations
- 2023Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implantcitations
- 2023Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implantcitations
- 2023Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications ; Fabrication, Structural, Electrical, and Biological Analysiscitations
- 2023Hydroxyapatite-Barium Titanate Biocoatings Using Room Temperature Coblastingcitations
- 2023Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applicationscitations
- 2022Characterization of a Biocomposite of Electrospun PVDF Membranes with Embedded BaTiO3 Micro- and Nanoparticlescitations
- 2019Using water to control electrospun Polycaprolactone fibre morphology for soft tissue engineeringcitations
- 2019Electrospun biodegradable chitosan based-poly(urethane urea) scaffolds for soft tissue engineeringcitations
- 2019Polymer blending or fiber blending: a comparative study using chitosan and poly(ε-caprolactone) electrospun fiberscitations
- 2018Synthesis, electrospinning and in vitro test of a new biodegradable gelatin-based poly(ester urethane urea) for soft tissue engineeringcitations
- 2017Evaluation of nanofibrous scaffolds obtained from blends of chitosan, gelatin and polycaprolactone for skin tissue engineeringcitations
- 2017Hybrid polysaccharide-based systems for biomedical applicationscitations
- 2016Natural Nanofibres for Composite Applicationscitations
- 2016A simple sol-gel route to the construction of hydroxyapatite inverted colloidal crystals for bone tissue engineeringcitations
- 2015Osteogenisis enhancement of hydroxyapatite based materials by electrical polarization
- 2014Electrical polarization of a chitosan-hydroxyapatite composite
Places of action
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article
Synthesis, electrospinning and in vitro test of a new biodegradable gelatin-based poly(ester urethane urea) for soft tissue engineering
Abstract
<p>Biodegradable polyurethanes have been studied as scaffolds for tissue engineering due to their adjustable physico-chemical properties. In this work, we synthesized a biodegradable gelatin-based poly(urethane urea) using polycaprolactone-diol, as soft segment, and isophorone diisocyanate and gelatin from cold water fish skin as hard segment. The synthesis was confirmed by Fourier transform infrared spectroscopy and proton nuclear magnetic resonance and the influence of the amount of gelatin introduced in the polymer backbone was analyzed by thermal analysis. Gelatin-based poly(urethane urea) electrospun fibrous mats and solvent cast films were then produced and their physico-chemical and biological properties studied. They present an amorphous structure, elastomeric behavior and water contact angles typical of hydrophobic surfaces. Hydrolytic degradation was analyzed in phosphate buffer saline (PBS), lipase and trypsin solutions. No mass changes were detected during 37 days in PBS and trypsin while significant degradation by lipase was observed. Human foetal foreskin fibroblasts were seeded on the fibrous mats and films. Populations were evaluated by colorimetric cell viability assays and morphology by fluorescence imaging. The substrates supported cell adhesion and proliferation. The novel gelatin-based poly(urethane urea) fibrous mats offer attractive physico-chemical and biological properties for soft tissue engineering applications.</p>